三亞甲基碳酸酯—丙交酯共聚物的合成、表征及其藥物控制釋放系統(tǒng)的研究.pdf

1、中國協(xié)和醫(yī)科大學(xué)碩士學(xué)位論文三亞甲基碳酸酯—丙交酯共聚物的合成、表征及其藥物控制釋放系統(tǒng)的研究姓名：肖凱申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：藥物化學(xué)指導(dǎo)教師：顧忠偉20060730中國醫(yī)學(xué)科學(xué)院，中國協(xié)和醫(yī)科大學(xué)碩士研究生論文摘要ABSTRACTBiodegradablepolymerisaveryimportantpartofbiomedicalmaterialsPolylactidehasbeenwidelyusedinmedicalappli

2、cations，suchassurgicalsutures、bonefixedmaterials、drugcontrolledrelease、scaffold，andSOon，foritsexcellentmechanicalproperty、goodbiocompatibilityandlowtoxicityInrecentyears，biodegradablepolycarbonatebecameoneofthemostattrac

3、tivebiomedicalmaterialsforitssomegoodpropertiesBiodegradablepolycarbonate、PolyesterandtheircopolymerarepromisingtobeusedinthebiomedicalfieldsThisarticlefocusedontheTMC、LAandtheirpolymerizationToimprovethepropertiesofhomo

4、polymers，it’Sagoodmethodthattosynthsisblockcopolymerorrandomcopolymer，byusingdifferentfeedcompositionFirstly，themonomers，TrimethylenecarbonateandD，L—Lactide，weresynthesizedandpurifiedwiththemodifiedmethodsofliteratureCop

5、olymersandhomopolymersweresynthesizedviaring—openingpolymerizationSn(Oct)2hasbeenchosentOstartthehomopolymerizationofTMCandD，L—LAandtheirrandomcopolymerizationPTMC、PDLLAandPTMC—CO—LAwereobtainedwithSn(Oct)2ascatalystathi

6、ghyieldSecondary，PolymersweretobecharacterizedThefeedcompositionsofcopolymerswere75／25、50／50and25／75Theactualcompositionsofthecopolymersweremeasuredby‘HNMRTheresultsshowedthatthefeedcompositionswerenearthecompositionsofc

7、opolymersThepropertiesoftheeopolymersandhomopolymerswereassayedbyDSC、GPC、DegradationinvitroFinally，themodeldrugreleasebehavioranddegradationbehaviorofsystemsbasedonthementionedaboveeopolymersandhomopolymerswereinvestigat