氨基酸與多羥基化合物相互作用的熱力學(xué)研究.pdf

1、曲阜師范大學(xué)碩士學(xué)位論文氨基酸與多羥基化合物相互作用的熱力學(xué)研究姓名：劉海波申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：物理化學(xué)指導(dǎo)教師：孫海濤20050401曲卑師范大學(xué)碩士學(xué)位論文AbstractAbstractAminoacids，whichhavebeenusedextensivelyasthemostimportantbiologicalmodelcompounds，arenotonlythebasicbuildingblocksofprotei

2、ns，butalsotheimPortantactivematerialsinlivingthingsSugarsandpolyolshelpinstabilizingthenativeconformationofglobularproteins，Therehasbeensignificantinterestintheinvestigationontheinteractioninaqueoussolutionsbetweenaminoa

3、cidsandorganicmoleculespresentinlivingorganismsorpossessingfunctionalgroupidenticalTheprinciplereasonsforstudyingsuchsystemsaretoobtaintheinformationthatcontributestothegrowingbodyofknowledgeaboutsolutesolvationandsolute

4、—soluteinteractionsinaqueousmedia，andabeaerunderstandingoftheirroleplayedintheconformationalstabilityandunfoldingbehaviorofproteinsThispapermainlyconsistsofthefollowingfivepartsThefirstpartsummarizesthegeneralstatesofstu

5、diesonthethermodynamicpropertiesofsystemscontainingproteinmodelmoleculesInthesecondpart，enthalpiesofmixingofaqueousaminoacidssolutions(glycine，Lalanine，L—serine，Lvaline，L—proline，Lthreonine)withaqueouspolyolssolutions(ma

6、rmitol，inosit01)havebeendeterminedat29815Kby2277flowmicrocalorimetricsystemTheseresultsalongwithenthalpiesofdilutionoftheseaqueoussolutionshavebeenusedtoobtaintheenthalpicinteractioncoefficients(hxyhxxy’hxyy)intermsofthe

7、McMillan—MayertheoryThepairwiseinteractionsbetweenaminoacidsandpolyolshavebeendiscussedbysolutesoluteinteractiontheoryInthethirdparttheenthalpiepairwiseinteractionsbetweensixkindsofaminoacidsandsaccharides(xylose，galacto

8、se)havebeendeterminedat31015KInthefonllparttheheterotacticenthalpicpairwiseinteractioncoefficientsbetweenaminoacidsandbutanedi01isomers(1，3butanediol，1，4butanedioland23一butanedi01)at29815Kand31015KarediscussedThechangeof