3-取代吲哚衍生物合成方法的改進(jìn).pdf

1、河北大學(xué)碩士學(xué)位論文3-取代吲哚衍生物合成方法的改進(jìn)姓名：孫少鋒申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：李記太2011-05Abstract II Abstract The synthesis of bisindolylmethanes, mannich bases, β- indolylketones, was reviewed in recent years. The synthesis of 3- s

2、ubstituted indole derivatives were improved by different methods. The reaction of aldehydes and indoles was obtained on 68- 98% yields at room temperature within 1- 5 min with grinding, catalyzed

3、 was by silicotungstic acid. The significant features of this procedure include higher yield and environment friendly. The reaction of secondary amine, formaldehyde and indole or N- methylindole ca

4、n be carried out in 69- 98% yields in acetic acid aqueous solution with 20- 290 min at 35 oC under ultrasound irradiation. Camphorsulfonic acid catalyzed the Michael addition of α,β- unsaturated

5、 ketones to indole under ultrasonic irradiation to afford the corresponding β- indolylketones. This method provides several advantages such as operational simplicity and higher yield. Keywords 3- subs