（S）-3-羥基-γ-丁內(nèi)酯及其衍生物（S）-1，2，4-丁三醇的合成研究.pdf

1、東南大學(xué)碩士學(xué)位論文（S）3羥基γ丁內(nèi)酯及其衍生物（S）1，2，4丁三醇的合成研究姓名：蔡征宇申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：劉舉正王明亮20040401東南大學(xué)頌學(xué)位論文Abstract(S)。3hydroxybutyrolactoneanditsderivative(S)1，24butanetriolareimportantbuildingblocksofasymmetricsynthesisandkeyintermedi

2、atesinthesynthesisofAtorvatitatin，L—camitine，ItlV一1proteaseamperanavirandothermedicinesaswell，SO，studiesontheirsynthesisareofgreatpracticalsignificance11lesynthesisof(s)3一hydroxybutyrolactoneand(s)1，24butanetriolarethema

3、jorworkofthisworkThefinalproductischaracterizedbyrotation，HNMRandIRwhichshowthatresultantsaretheobiectiveproducts(S)_3hydroxybutyrolactonehasbeensynthesizedbydecomposingofhexoseAndthatisgoodforenvironmentandofpromisingpr

4、ospectforapplicationWithsodiumhydroxideandhydrogenperoxidebeingtheoxidizer，maltosewasoxidizedanddecomposedinto(S)3，4一dihydroxyl—butyricacid，whichwascycledandesterifiedtoobtains3一hydroxybutyrolactoneThefinalproductwaspuri

5、fiedbyflashchromatography(S)一3hydroxybutyrolactonehasbeensynthesizedbythewaythatL—malilcacidisanhydridised，esterified，andreducedbyNaBH4followedbyhydrationmadcyclinginto(S)一3一hydroxybutyrolactoneEffectsofcatalyst，dosageof

6、solvent，additionofrawmaterials，reactiontimeandtemperatureonproductyieldarestudiedTheoptimumreactionconditioninwhichtheyield“WaSupto79％isdeterminedTheroutehasadvantagesoffewbyreaction，highyieldandeasyoperation(S)1，2，4buta

7、netriolhasbeenproducedusingLmalicacidasrawmaterialDimetyl一LmalicesterthatisproductofesteriflcationofL—malicacidandmethanolisreducedbyNaBHaandLithiumchloridefollowedbyseparationandpurificationtoobmined(s)一1，2，4一butanetri0

8、1(s)一1，2，4butanetriolwasanalyzedbyHPLCResultsindicatedthatthepurityis9467％withtheyieldupto68％Someimprovementsinseparationprocesshasbeendoneinordertoincreasetheproductpurity，andsimplificationoftheopeamtionmakestheroutegof

9、orwardonesteptoindustrialization(s)1，2，4butanetriolhasbeensynthesizedwith(s)一3hydroxybutyrolactoneasrawmaterialBeingmothermaterialforthefirsttime，(s)一3一hydroxybutyrolactoneisreducedbyNaBH4thatwasmildandofhighreactionsele

10、ctivitytoproduce(S)1，2，4butanetri01Effectsofadditionorderandmolarratioofrawmaterials，reactiontimeandtemperatureonproductyieldareinvestigatedThebetterreactionparameters，inwhichtheyieldismorethan82％，aredeterminedTherouteis