ERCC1、BRCA1、Ki-67的表達與乳腺癌CEF新輔助化療療效的相關性研究.pdf

1、新疆醫(yī)科大學碩士學位論文ERCC1、BRCA1、Ki67的表達與乳腺癌CEF新輔助化療療效的相關性研究姓名：閆梅申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：王振華201104新疆醫(yī)科大學碩士學位論文新疆醫(yī)科大學碩士學位論文2CrelativeresearchofexpressionofERCC1BRCA1Ki67outcomeofCEFneoadjuvantchemotherapyofBreastCancerPostgradua

2、te:yanmeisupervis:profwangzhenhuaAbstractObjective:ToinvestigatethechangeofERCC1BRCA1Ki67inbreastcancertissuethroughCEFneoadjuvantchemotherapyassociationwithpathologicrespone.Methods:Breastcancerspecimenswerecollectedfro

3、m47patientswhounderwentoperationFNBintheAffiliatedTumHospitalofXinjiangMedicalUniversityduringJan.2004toOct.2009.TheexpressionofERCC1BRCA1Ki67inthebreastcancertissueweredeterminedbyimmunohistochemicalstaining.Results:The

4、rewasnodifferencebetweentumsizehistologicgradepatient’sagecancertypeexpressionofERPRpathologicresponseofCEFneoadjuvantchemotherapy(P0.05)ThechemotherapyefficiencyfERCC1responserwaslowerthanERCC1nonrespomser(11.1%vs41.4%P

5、0.05)TherewasstasticaldifferenceinexpressionofERCC1betweenprechemotherpypostchemotherpy(31.7%vs58.5%P0.05)buttherewasnotstatisticaldifferenceinexpressionofBRCA1betweenprechemotherpypostchemotherpy(36.6%vs46.3%P0.05)Posit

6、iverateofKi67ineffectivegroupnoneffectivegroupis77.8%，44.8%respctivelytherewasstatisticaldifference(P0.05).Conclusion:PathologicresponseofCEFneoadjuvantchemotherapywasnotinfluencedbyclinicalpathologicalfeaturestosomeexte

7、ntitupregulatedexpressionofERCC1whichcanoffersomereferencefsussessivechemotherapyafteroperationThehighexpressionofKi67impliedthebettersensitivitytoCEFneoadjuvantchemotherapywhichshouldbeconsideredinclinicaltherpy.Keywds: