藥物-環(huán)糊精超分子體的制備及表征.pdf

1、7j“‘7IPS，，，j，。。r∽e，索取號(hào)：Q魚3魚：!』!：壘!!密級(jí)：公五南京坪勉犬掌碩士學(xué)位論文園藥物／環(huán)糊精超分子體的制備及表征作者：院系：指導(dǎo)教師：學(xué)科專業(yè)：余麗麗一一1麗兩擎蕊～楊星吳副教授碩旨一塑些掌與分子生墊學(xué)碩士學(xué)位論文藥物，環(huán)糊精超分子體的制各及表征AbstractSupramolecularisformedbyhostandguestmolecularwhenaguestmolecularisfullyorpar

2、tlyincludedinthestructurespaceofahostmolecularCyclodextrins(CD)，withsuitablemolecularsizeandexcellentbiocompatibility，aretheimportanthostrnolecularsofsupramolecularsintheresearchandapplicationofdrugsWhenthedrugisincluded

3、intothecarityofthecyclodex倒_nmolecule，someinteractionwillhappenandthusthepharmaceuticalpropertieswillbeimprovedVolatileoilofBaizhuandnimodipineweretakenasexamplesinthisstudyOrthogonaldesignmethodwasemployedtooptimizethet

4、echniqueofextractionofvolatileoilandthepreparationofvolatileoilofBaizhu／1]一CDNimodipine／HP—B—CDinclusioncomplexeswithdifferentmolecularswerepreparedexperimentallybydifferentmethods(kneaded，丹eeze—dryingandspray—drying)The

5、drug，CDandtheirbinarysystemswerecharacterizedbydifferentialscanningcalorimetryFouriertransformation—infraredspectroscopy，XraydiffractometryandscanningelectronmicroscopyandSOonWiththecomputeraidedsimulator，theinteractionb

6、etweendrugandCDWaseventuallywellcharacterizedAseriesofevidentcharacteristicsofvolatileoilofBaizhu／p=CDinclusioncomplexwerepresentedinDTA，XRD，F(xiàn)TIRandSEM，indicatinganimprovementofpharmaceuticalpropertiesGCandTLCanalysissho

7、wednsthatthenaturalcompositionofthevolatileoilhadbeenchangedwiththeunchangedessentialcomponentsNimodipineandHP—B—CDhostguestinteractionwerecharacterizedbyphase—solubilitystudy，DTA，F(xiàn)TIR，SEManddissolutionstudy，exceptforXRD

8、Withthecomputer—aidedsimulator，theconjugationmodalityofnimodipinewassuccessfullydeterminedAllthesecharacterizationscouldnotonlyhelpUStoestimatetheinteractionbetweenthehostandguest，butcouldbetheguidanceofthepredictionofth