超支化星形兩親性SPLA-b-PDMAEMA聚合物的合成及其納米微粒的制備與表征.pdf

1、天津大學碩士學位論文超支化星形兩親性SPLAbPDMAEMA聚合物的合成及其納米微粒的制備與表征姓名：龍麗霞申請學位級別：碩士專業(yè)：材料學指導教師：原續(xù)波201006ABSTRACTCalciumphosphatecement(CPC)hasbeenwidelyconsideredasgoodbonerepairmaterials，whichshowsexcellentbiocompatibilityandosconductibilit

2、yandcanbemoldedtoanydesirableshapeduringoperationwithoutheatreleaseHowever，themechanicalpropertyofCPCisnotenoughtobeusedasstressbeatingbonescaffolds，andthelackofmacroporesandslowdegradationhindersitswideclinicalapplicati

3、onsAsaresultthemodificationonCPChasaveryimportantpracticalsignificanceInthispaper，gelatinmicrospheres(GMslanda—calciumsulfatehemihydrate(0cCSH)wereaddedtoixTCPbonecementpowdertopreparemacroporousscaffolds，andthehydration

4、reactionwasperformedinsimulatedbodyfluid(SBF)XRD，F(xiàn)Tl＆SEM，EDSandTEMwereusedtocharacterizethephasecompositionandmicrostructureofthehydrationproductsThesettingtimeandmechanicalpropertiesweretestedneresultsshowedthatthemainc

5、rystalphaseofCPCscaffoldsresultedfromthedissolutionofmicrospheresaftertwoweekssoakinginSBFwaspoorlycrystallinehydroxyapatite(HAp)，whichwasthesameasthatofCPCscaffoldswithoutcontainingGMs111escaffoldwith10wt％GMshasaporosit

6、yof61％andacompressivestrengthof45MPaaftertwoweekssoakinginSBFwhilewiththeincorporationof20wt％GMsintoCPC，theporositywas74％whichincreasedby21％，andcompressivestrengthwas25MPadecreasedby5l％Itmeansthattheporosityofthescaffold

7、increasedslowlywhenthecontentofGMswasmorethan10wt％，whilethecompressivestrengthdecreasedgreatlyBasedontheporosityandcompressivestrength，10wt％GMswereselectedtoaddtotheCPCpowderWiththeadditionoflOwt％IxCSH，thesettingtimedecr

8、easedto19minutesfrom34minutes，andtheporosityincreasedslightlyMicrostructureanalysisfoundthehydrationproductHApwassmallerandgrewalongCaxistoformrod1ikegrain，whichresultedintheincreaseofthecompressivestrengthandtoughnessof

9、thesettingproductsEDSanalysisfurtherrevealedthatthehydrationproductofthescaffoldwithl0wt％0t—CSHadditionwascalciumdeficientHApwithacalciumtophosphorusmolarratioof160，whichwasmuchlowerthanthatofthescaffoldwithout0【CSH(166)