糖類抗原19-9在膀胱癌患者尿液及腫瘤組織中的異常表達.pdf

1、上海醫(yī)科大學碩士學位論文糖類抗原199在膀胱癌患者尿液及腫瘤組織中的異常表達姓名：袁昆申請學位級別：碩士專業(yè)：外科學(泌尿外科)指導教師：張元芳20000601ABS’rRACTAbnormalElevationofUrinaryCarbohydrateAntigen19—9anditsEnhancedExpressioni11TumorTissueofPatientswithTransitionalCellCarcinomaofthe

2、B1adderTransitionaleellcareinoma(TCClofurinarybladderhasbeenestimated幻beoneofthemostcommonttrologicalmalignanciesSensifivediagnosticmethodsarerequiredforthesurveillanceanddetectionofTCCdueto11i￡hrecurrenceManynoninvasive

3、urinarytumormarkersarousegreatinterestamongurologistsThroughmethodofIlnmtmoluminescenceassaywedeterminetheurinaryvalueofCarbohydrateAntigen19—9fCAl991in30casesofconfirmedTCC22healthysubjectsand110patientswithotherbenigna

4、ndmalignantdiseaseslmmtmohistochemicalstudyiSalSOcarriedtomvestigatetheexpressionofCAl99inTCCof35patientsand5controlsWefoundtheurinaryCAl99inpatientswithTCCiSstatisticallyhigherthanthatofpatientswithothertwologicalmalign

5、anciesandbenigndiseasesInadditiontheurinary1evelofCAl99withTCCWasfoundtobesignificantlysmpassingthatofalimentarytractmalignanciesandofhealthcontrolswhilenotdifieringfromUrolithiasisandRenalCellCareinomasi_nlificantlyThep

6、revalentexpressionofCAl99inRlmortissuesandscarcedistributionjnnomlalcontrolsareprovedthroughIrmnunohistochemistrystainingandthepositiverateinTCCiSestimatedtobe943％Setting260U／Lascuto巧DointthroughRoCanalysis，thesensitivit

7、yofurinaryCAl99determinationiS767％anditsspecificityiS653％innonTCCurologicaldiseasesTheaccuracyiS72，2％forthediagnosisofTCC，whicharecomparabletoothertumormarkersThefalsepositiverateis396％iflbenignurolo卣caldiseasesThediffer

8、entiallevelofthisbiomarkerregardingthemostrelevanthistologicalandclinicalparametersarealsoassessedInconclusionCAl9—9appearstobeapromisingandnoninvasivet001todetectTCCofbladderItssensitivityandclinicalavailabilityjustifyf