A Retrospective and Clinical Analysis of Ulcerative Colitis，A report of 50 cases.pdf

1、Ulcerative colitis (UC) is a chronic disease characterized by diffuse mucosal inflammation limited to the colon. It involves rectum in-about 95％ of cases and may extend proximally in a symmetrical,circumferential and uni

2、nterrupted pattern to involve parts or all of large intestine[1]. The disease is more common in Caucasians than in Blacks or Orientals with an increased incidence (three to six fold) in Jews[2,3]. In US, the disease acco

3、unts for a quarter million physician visits annually, 20,000 hospitalizations and loss of over a million work-loss days per year[4]. In China, number of UC patients have increased significantly in the past 10 years[5]. T

4、he incidence of UC varies greatly in different geographical areas of the world[6]. Ulcerative colitis was first described by Sir Samuel Wilks in 1859[7]. The first case reported in China was in 1956[8]. The etiology

5、of UC is still not clear. UC is a non-specific chronic inflammation involving mucosa and sub mueosa. The hallmark clinical symptom is bloody diarrhea often with symptoms of rectal urgency and tenesmus [9]. The clinical c

6、ourse is marked by exacerbations and remissions which may occur spontaneously or in response to intereurrent illness [10]. Colonoscopy or Proctosigmoidoseopy and biopsy are the test of choice to diagnose ulcerative colit

7、is. Characteristic changes include loss of of typical vascular pattern, friability, exudates, ulceration and granularity in a continuous, circumferential pattern [11] as seen in figures 1-6.Medications used in treatin