藻酸雙酯鈉對急性腦梗死的臨床效果及其機理研究.pdf

1、蘇州大學碩士學位論文藻酸雙酯鈉對急性腦梗死的臨床效果及其機理研究姓名：馬麗麗申請學位級別：碩士專業(yè)：血液內科指導教師：王兆鉞尹明達20071001ClinicalE丘鰍ofPolysaccharideSul缸einPati即tsw油AcutcCelebraJIn衙ct鋤ditSMech姐i湖ClinicalEf!IfectofPolysaccharideSulfateinPatientswithAcuteCelebralInfarcta

2、nditsMechanismAbstract0bjective：Tostudyclinicalef聶x過ofpolysaccharidesulfateinpatientswithacutecelebralinfarct(ACI)anditSmechallismMethods：Patientssuf如ringfromAClwithinoneweekwererandomlydevidedinto3groupsreceiVingpolysac

3、charidesulfate(PSS)，aspirin(ASA)andticlopidine(TP)，respectiVely‘ThefoIlowingindicesweremeasuredbeforetreatmentand3d，7d，l4daftertr皇atment：plateletaggregationrate(PAGR)，pl私maP—selectin，也rombox齜圮B2(1Ⅻ2)inpa虹伽陷，PT，APTT，TT，nb

4、rinogen(Fg)，serumlipidsaswellasnerVousfhnctionResults：①PssinhibitedPAGinducedbyADPandarachidonicacid(AA)WhileASAmainlyinhibitedAAinducedPAG，andTPmainlyinhibitedADPinducedPAG(參PSS，ASAandTPdecreasedthelevelofplasmaPselecti

5、naftertreatmentthelevelofplasmaTXB2wasdecreasedsignificantlybyASAaftertreatment，butnotbyPSSorTP(螢APTTwasprolongedbyPSS，andPTwasslightlyprolonged，whileTTandFgwasnotchangedOntheotherhand，ASAandTPhadnoef代ctoncoagulationtest

6、s(DserumlipidwassignificantlydecreasedbyPSS，butnotbyASAorTP(9nervousfunctionwasbetterrecoVeredinPSSgroupthanASAandTPgroups‘ConcIusion：PSSshowsanantithromboticefIfectthrough1ipiddecrease，coagulationinhibitionandplateletin