雛菊葉龍膽對坐骨神經損傷后神經修復作用的實驗研究.pdf

1、分類號——ICS——學校代碼lQ!墨墾學號2Q!QQ絲12委l￡～菱一墨復內蒙名民蓯大學碩士學位論文雛菊葉龍膽對坐骨神經損傷后神經修復作用的實驗研究StudiesonBellidifolintoNeurorehabilitationafterSciaticNerveInjury申請人：劉鑫學科專業(yè)：中西醫(yī)結合臨床研究方向：蒙西醫(yī)結合外科學學位類別：專業(yè)學位指導教師：杜彥李教授論文提交日期：二O一三年四月theExperimentalSt

2、udyofBellidifolinEnhancingRehabilitationofInjuriedSciaticNerveAbstractObjective：TostudywhethertheBellidifolinhavetherehabilitationeffecttoinjuriedsciaticnerverat，toexplorewhetherCiliaryNeurotrophicfactor(CNTF)isinvolvedi

3、nthismechanism，tomakebasicfoundationforfurtherinvestigationMethods：Malewistarrats225tomakesciaticnerveinjuriedmodel，withrightsciaticnerverWascutandsewedundermicroscopyleftsciaticwasshamRatdevidedinto5groupsrandomizely，as

4、controlgroup，Bellidifolin25raggroup，50mggroup、75mggroupandMecobalamingroup，eachgroupwere45ratsControlgroupjustinjectedsodiumchloride，othersperitonealinjecteddifferentdoseofBellidifolinandMecobalaminafteropermionDetectedf

5、ootprintafter1，3and5weeks，countedtheSciaticFuntionIndex(SFI)，MotorNerveConductionVelocities(MNVC)，TricepsSuraeWeight(TSW)，immunochemicalmethodanalysedCNTFexpressin。Results：(1)SFIresults：1weeksafteropermion，controlgroup，m

6、ecobalaminggropandBellidifolin25mggroup，50mggroup，and75mggroupwere：～8435士487，一4520i230，一7042士421，一5773士346and一6438士438，comparedwithcontrolgroupothershaddifferences(P005)，Bellidifolingroupsversusmecobalaminggroup，therewer

7、estatisticallydifferences(P005)，withinBellidifolingroups，50mggrouphaddifferencecomparedwith25mgand75mggroups(P005)(2)theNMCVThelargestamplitudandTSWalsoshowedthereweredifferencesamongbellidifolingroups，controlgroupandmec

8、obalaminggroupEvenwithinBellidifolingroups，50mggroupcomparedwith25mgand75mggroups，therewerestatisticallydifferences(P005)(3)3weekscomparedeachgroupswithImmunohistochemistryanalysis，CNTFexpressionshowedtherewerestatictica

9、llydifferencesamongbillidifolin50raggroupand25mg，70mggroupsof50mggrouparehigherthanothers(P005)Conclusions：(1)BellidifolinCanelevatetheSFIvalureofcutandsewedsciaticnerverimprovethemotornerverconductvelocityandtheweightof

10、tricepssurae(2)TheconcentrationofBellidifolin50mghasbettereffectthan25mgand75mg(3)Bellidifolincanimprovetheinjuriedsciaticrehabilitation，andCNTFisinvolvedKeyWords：Bellidifolin：sciaticnerve；nerveinjur：nerverehabilitation：