雛菊葉龍膽對(duì)坐骨神經(jīng)損傷后神經(jīng)修復(fù)作用的實(shí)驗(yàn)研究.pdf

1、分類號(hào)——ICS——學(xué)校代碼lQ!墨墾學(xué)號(hào)2Q!QQ絲12委l￡～菱一墨復(fù)內(nèi)蒙名民蓯大學(xué)碩士學(xué)位論文雛菊葉龍膽對(duì)坐骨神經(jīng)損傷后神經(jīng)修復(fù)作用的實(shí)驗(yàn)研究StudiesonBellidifolintoNeurorehabilitationafterSciaticNerveInjury申請(qǐng)人：劉鑫學(xué)科專業(yè)：中西醫(yī)結(jié)合臨床研究方向：蒙西醫(yī)結(jié)合外科學(xué)學(xué)位類別：專業(yè)學(xué)位指導(dǎo)教師：杜彥李教授論文提交日期：二O一三年四月theExperimentalSt

2、udyofBellidifolinEnhancingRehabilitationofInjuriedSciaticNerveAbstractObjective：TostudywhethertheBellidifolinhavetherehabilitationeffecttoinjuriedsciaticnerverat，toexplorewhetherCiliaryNeurotrophicfactor(CNTF)isinvolvedi

3、nthismechanism，tomakebasicfoundationforfurtherinvestigationMethods：Malewistarrats225tomakesciaticnerveinjuriedmodel，withrightsciaticnerverWascutandsewedundermicroscopyleftsciaticwasshamRatdevidedinto5groupsrandomizely，as

4、controlgroup，Bellidifolin25raggroup，50mggroup、75mggroupandMecobalamingroup，eachgroupwere45ratsControlgroupjustinjectedsodiumchloride，othersperitonealinjecteddifferentdoseofBellidifolinandMecobalaminafteropermionDetectedf

5、ootprintafter1，3and5weeks，countedtheSciaticFuntionIndex(SFI)，MotorNerveConductionVelocities(MNVC)，TricepsSuraeWeight(TSW)，immunochemicalmethodanalysedCNTFexpressin。Results：(1)SFIresults：1weeksafteropermion，controlgroup，m

6、ecobalaminggropandBellidifolin25mggroup，50mggroup，and75mggroupwere：～8435士487，一4520i230，一7042士421，一5773士346and一6438士438，comparedwithcontrolgroupothershaddifferences(P005)，Bellidifolingroupsversusmecobalaminggroup，therewer

7、estatisticallydifferences(P005)，withinBellidifolingroups，50mggrouphaddifferencecomparedwith25mgand75mggroups(P005)(2)theNMCVThelargestamplitudandTSWalsoshowedthereweredifferencesamongbellidifolingroups，controlgroupandmec

8、obalaminggroupEvenwithinBellidifolingroups，50mggroupcomparedwith25mgand75mggroups，therewerestatisticallydifferences(P005)(3)3weekscomparedeachgroupswithImmunohistochemistryanalysis，CNTFexpressionshowedtherewerestatictica

9、llydifferencesamongbillidifolin50raggroupand25mg，70mggroupsof50mggrouparehigherthanothers(P005)Conclusions：(1)BellidifolinCanelevatetheSFIvalureofcutandsewedsciaticnerverimprovethemotornerverconductvelocityandtheweightof

10、tricepssurae(2)TheconcentrationofBellidifolin50mghasbettereffectthan25mgand75mg(3)Bellidifolincanimprovetheinjuriedsciaticrehabilitation，andCNTFisinvolvedKeyWords：Bellidifolin：sciaticnerve；nerveinjur：nerverehabilitation：