解毒散結(jié)合劑聯(lián)合CHOP方案治療非霍奇金淋巴瘤的臨床研究.pdf

1、分類號(hào)： R2-031 密級(jí)：不保密UDC：615.8 學(xué)校代碼：11065碩士學(xué)位論文解毒散結(jié)合劑聯(lián)合 CHOP 方案治療非霍奇金淋巴瘤的臨床研究 解毒散結(jié)合劑聯(lián)合 CHOP 方案治療非霍奇金淋巴瘤的臨床研究陳磊 陳磊指 導(dǎo) 教 師 谷萬里 主任醫(yī)師學(xué)科專業(yè)名稱 中西醫(yī)結(jié)合臨床論文答辯日期 2 0 1 5 - 0 6 - 0 6Clinical observation of Jiedu Sanjie Heji decoction in

2、 combination withCHOP chemotherapy for non-Hodgkin's lymphomaAbstractObjective: To observe the clinical curative effect of the Jiedu Sanjie Heji decoction combined with CHOP chemotherapy in the treatment of non-Hodgk

3、in's lymphoma.Methods: 60 patients of non-Hodgkin's lymphoma by random principle is divided into treatment group 30 cases，30 cases of the control group. The control group was treated with conventional CHOP chemot

4、herapy regimens. The treatment group was treated withoral Jiedu Sanjie Heji decoction combined with CHOP chemotherapy regimen. 21 days for one treatment course. The clinical effects were evaluated after 2 treatment cours

5、es.The examinations in each treatment course include blood routine，liver function，renal function and electrocardiogram. These examinations were examined as safety observation index . Each of the two treatment course CT o

6、r/and B-ultrasound，LDH and bone marrowaspiration were examined to observe the lesions and bone marrow is invaded， and used asthe basis for evaluation of clinical emcacy. Results: In two groups after the treatment can red

7、uce the mass，the treatment group total effective rate was 96.67%， compared to thecontrol group in the total efficiency was 76.67%， P＜0.05 between the two groups. Thedifference was statistically significant ， description

8、of the treatment group and controlgroup after treatment equivalent clinical efficacy. 7 cases of the control group appear disease progression，and only 1 case has shown in the treatment group.WBC， after treatment of the d

9、igestive system toxicity in two groups after treatment have statisticallysignificant (P 0.05）. Significant damage to liver and kidney function and cardiac toxicity reactions were not found during treatment in the two gro

10、ups. Conclusion: By Oralling the Jiedu Sanjie Heji decoction incombination with CHOP chemotherapy can effectively relieve patients with non-Hodgkinlymphoma tumor load， reduced the mass. Its clinical efficacy was signific

11、antly better than single application of CHOP chemotherapy. There were no obvious toxic side reaction. It is a simple， safe， effective， economic， practical， feasible treatment method. It is worthyof clinical promotion and