運(yùn)動訓(xùn)練對新生期大鼠反復(fù)驚厥所致學(xué)習(xí)能力損害的干預(yù)及機(jī)制探討.pdf

1、蘇州大學(xué)碩士學(xué)位論文運(yùn)動訓(xùn)練對新生期大鼠反復(fù)驚厥所致學(xué)習(xí)能力損害的干預(yù)及機(jī)制探討姓名：蔣偉明申請學(xué)位級別：碩士專業(yè)：兒科學(xué)指導(dǎo)教師：王浙東倪宏20080401Themechanismoflongtermeffectsofphysicalexerciseonneonatalseizure—inducedcognitivedeficitAbstractThemechanismoflongtermeffectsofphysicalexerci

2、seonneonatalseizureinducedcognitivedeficitAbstractObjeetiveToexplorethelong—termeffectsofneonatalseizuresandphysicalexerciseonlearningandmemorycapacity。MethodsTheratswererandomlydividedintotherecurrent—seizuregroup(RS)an

3、dthecontrolgroupThevolatileagentflurothylwasusedtoinduce30minseizureattackAtpostnatalday6(P6)，therecurrentseizureswereinducedonce‘perdayforconsecutive6daysControlratswereplacedintothecontainerforanequalamountoftimetothei

4、rcounterpartwithoutexposuretoflurothylAtP29～P35、P61“√P67，Ymazetestwereperformedtoevaluateleamingandmemorycapacity。Duringthistime，atP51～P56，theRSandcontorlgroupsweresubmittedtoanaerobicexerciseprogram30minperdayforconsecu

5、tive6daysAtlast，wedetectedtheexpresstionofGluR2inhippocampusResultsYmazediscriminationleamingtest：InthefirstYmazetest，therewassignificantdifferencebetweenthetrialstocriterioninRSgroupandcontrolgroups(P005)Therewassignifi

6、cantdifferenceexpresstionofGluR2betweentheRSgroupandcontrolgroupsConclusionsWhileneonatalseizureshadlongtermeffectonspatiallearningandmemoryphysicaltrainingcarlpartlyreverseitTheeffectofsingleprolongedseizureonleamingand