骨肉瘤中MICA蛋白表達和脫落機制研究.pdf

1、中山大學博士學位論文骨肉瘤中MICA蛋白表達和脫落機制研究姓名：盧善明申請學位級別：博士專業(yè)：病理學與病理生理學指導教師：薛玲20080531中山大學博士學位論文骨肉瘤中MICA蛋白表達和脫落機制研究屬蛋白酶能蓁耋霧鐾垂冀蓁MICA翼霎：蓁霎囊蓁蓁萋霎囊蓁MICA(sMICA)i墓薹霧霧霧蓁毳甬選冀霧氍霧NKG2D簍囂鍪莖墓露耍霎耋蠶蓊囂萋i酉蓖霾萋NKG2D冀霪翼萋蠶墓蓁蠢理萋i蠡璧。MICA霉|l|羹霞蠹龔霧鐾薰薹耋蓁羈NKG2D塑

2、霪蕢琵；冀霞鬟覆圈T霧醛壁薹；蓁鬟霞豁MICA鰓cyandpredominantlyoccurs0ntheChildaIldtlleteenageTlle5yearsurviValrateforpatients、析nlor、析thoutmetaSt戚sandrecu玎encesis20—30％鋤d60％70％，reSpectivelyIllamurinemodelofogceosarComametastases，Tcenimmuller

3、esponsesplayedacriticalroleindete姍iIlingwhetllermet蝴sesdevelopedTherefore，amorecomprehensiveunderstaIldingtotumorimmuneevasionisrequiredfortlletreatmentofosteosarcomaNKG2DreceptorisexpressedonNKcells，CD8npTcells，丫6TceUsa

4、11dasubsetofCD4十0【pTcellsTheinteractionbetweenNKG2DandNKG2D1igand(NKG2DL)directlytriggerSNKcellcytotoxicactiv毋andcostimulatesCD8TcellcytotoxicaCtiVi妙MHCclassIchainrelatedmoleculeA(MICA)ismem旬orligaIldofhumallNKG2Drecepto

5、rMICAgenelocatesintlleh啪觚HLAlocusencodingtypeImmsmemb啪eproteinMICAisabsentorshowSlowexpressiononno咖altissuesUpregualtionofNKG2DLexpressionc鋤befoulldaRercellsendureds仃ess，bacteria／viraliⅡfectiona11dneommsfoHIlationMICAcon