慢性癲癇病人癇性發(fā)作與海馬代謝物異常相關(guān)性磁共振波譜探討.pdf

1、華中科技大學(xué)碩士學(xué)位論文慢性癲癇病人癇性發(fā)作與海馬代謝物異常相關(guān)性磁共振波譜探討姓名：韓海偉申請學(xué)位級別：碩士專業(yè)：影像醫(yī)學(xué)與核醫(yī)學(xué)指導(dǎo)教師：徐海波201005華中科技大學(xué)碩士學(xué)位論文華中科技大學(xué)碩士學(xué)位論文2Crelationofseizurewithmetabolicdysfunctioninhippocampusby1HmagicresonanceimaginginchronictempallobeepilepsyAbstract

2、ObjectiveToexplethecrelationbetweenseizuremetabolicdysfunctionofneurongliacellinthehippocampusinchronictempallobeepilepsy(cTLE)toimproveourunderstingofprogressivechangestheunderlyingmechanismsinthechronictempallobeepilep

3、sy.MethodsMaterials41patientswerediagnosedascTLEbycomprehensiveuseofclinicalhistyneurologicalexaminationscalpEEGwithsphenoidalelectrodesconventionalmagicresonanceimaging(cMRI)thenmultiplevoxelMRchemicalshiftimagingwasper

4、fmed.Therewere21men20womenwiththeageof8to56years(meanage2422years).20healthyvolunteerswithknownhistyofnoneurologicaldiseasewererecruitedascontrol.AnanalysiswasperfmedinthecrelationofseizuredurationwiththeratioofNAA(ChoCr

5、)inthehippocampusipsilateraltoepileptogenesisfocicontralateraltoepileptogensisfoci.Meoverthenthepatientsweredevidedintotwogroupsaccdingtotheseizurefrequency(≥1permonth＜1permonth)thedifferenceoftheratioofNAA(ChoCr)inthehi

6、ppocampuswasinvestigatedbetweenthetwogroups.ResultsTheratioofNAA(ChoCr)tendedtoincreasealongbothhippocampiintheposteroanteridirectioninpatientswithcTLEinthecontrol.TheratioofNAA(ChoCr)wassignificantlydecreasedintheheadbo

7、dytailofthehippocampusinthecTLEcomparedtothecontrolgroup.ButinthecTLEpatientsnosignificantcrelationwasfoundbetweentheseizuredurationtheratioofNAA(ChoCr)inthehippocampusipsilateraltoepileptogensisfocineitherwasinthehippoc

8、ampuscontralateraltoepileptogensisfociTheratioofNAA(ChoCr)intheheadofthehippocampusipsilateraltotheepileptogensisfociwassignificantlylowerinthegroupofseizurefrequencywithmethanoncepermonththanthegroupwithlessthanonceperm

9、onth(P＜0.05).nosignificantdifferencefoundinthebodytailofthehippocampusipsilateraltotheepilepogensisfoci.ConclusionsInthechronictempallobeepilepsyourfindingssuggestedthatneuronalcelllossdysfunctionmayoccurinthehippocampus