支氣管哮喘病兒血清白細(xì)胞介素13水平變化及意義探討.pdf

1、青島大學(xué)碩士學(xué)位論文支氣管哮喘病兒血清白細(xì)胞介素13水平變化及意義探討姓名：郭興青申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：兒科學(xué)指導(dǎo)教師：張秋業(yè)20041204英文摘螫THESTUDYoNCHANGESoFSERUMINTERLEUKIN—l3ANDTHEIRSIGNIFICANCEINCHILDRENWITHASTHMAABSTRACTObject／re：z6studythechangesandcorrelationofSerUiTliqterleu

2、k／n一13、totalIgEandpefipheralbloodeosinophilcountsinasthmaticchildrenMethods35asthmaticchildren(theacutegroupandtheremissiongroup)and20healthychildren(thecontrolgroup)wereselectedDouble—andbodyELISAwasusedtodetectthelevel

3、sofserumIL13andTIgEPBECmeasurementxvasperformtdinthemeantinqcbytheauto—bloodanalysorResults‘TheresultsillustratethatthelevelofserumIL一13duringthechildren’Sattackperiod(4372681)ng／Lwassignificandyhigherthanthatduringthere

4、missionperiod[(3302439)rig／L]andintheirnormalperiod[(1763239)ng／L]，thedifferencehadhighlystaristicalsignificant(q=lO67，2453，respectively，P001)：ThelevelofserumtotalfgEWasf(689964343)IU／mL]andPBECCOUfltSwere【(114952530)106

5、／L]duringthechildren’sattackperiod1twasobviouslyhigherintheacutegroupthanthatintheremissiongroup【(44141H933)IU／mL]、【(100282191)106／L]andintheircontrolgroup【(122183127)IU／mL]、【(62791454)106／L]，thedifferencehadhighlystatis

6、ticalsignificant(q=2013，341，P001。005；respectirely，q=4412，1145，P001)ThelevelsofserumIL一13、totalIgEandPBECcountsdecreasedmarkedlyintheremissiongroup，butwerestillhigherthanthoseinnormalcontrolgroupandthedifferencehadhighlys

7、tatisticalsignificanttoo(q=1447，2514，823，respectively，P001)ThelevelofserumIL13(theattackgroupandremissiongroup)correlatedpositivelywithserurnTIgEan4PBECcounts(r=0653，0324，respectivelyP001)Conclusion：ThelevelofserumIL一13i

8、ssignificandyhigherinasthmaticchildrenThereisasignificantlypositivecorrelationbetweenscrLIITIIL一13andserumTIgE0rPBECcountsIL13hasregulatedandparficipatedinIgEsynthesis，itisaregulatorinthepathogenesisofasthmaandmayplayani