連續(xù)小劑量米非司酮對卵巢功能及子宮內膜發(fā)育的影響.pdf

1、復旦大學碩士學位論文連續(xù)小劑量米非司酮對卵巢功能及子宮內膜發(fā)育的影響姓名：林穗青申請學位級別：碩士專業(yè)：婦產科指導教師：李紅2001.10.1英文摘要TheEffectsOfContinuousLowDoseMifepristoneOnOvarianFunctionAndEndometrialDevelopmentobjective：Tostudytheeffectsofcontinuouslowdosemifepristoneonov

2、arianfunctionandendometrialdevelopment，andtheeffectsonwomen’SmenstrualcycleandvisceralfunctionsideeffectsToexploretheabilityoflowdosemifepristonewouldbepillMethods：ThestudyiSadoubleblindrandomizedcomparativetrialSelectfo

3、rtywomen，theyhavegoodhealthandnormalmenstrualcycle，havebeendividedintotwogrouprandomlyGroupI(20women)take2mgmifepristonedailyGroupⅡ(20women)take5mgmifepristonedailytotal120days(fourmenstrualcycles)Thecourseofstudyare180d

4、aysIncludepretreatmentcycle(30days)，treatmentcycle(120days)，post—treatmentcycle(30days)WomentakemifepristonefrointhefirstdayofmenstrualcycleWomenhavebeenaskedtokeepurinespecimenonceaweektomeasllreE，P2Wehavegivenwomenacar

5、dtecordvaginalbleedingeverydayEveryvisitingwehavegottenwomen’Sbloodspecimentomeasllre聲峨Cr，Bun，lib，BPC，E2，P’FSH，LH，PRL，ACTH，Cortisol，K，Na，C1‘，etcEveryvisitingwomenhavebeenexaminedovaryfollicleandendometrialthicknessbyvagi

6、nalultrasoundInthestudywehavethreetimesendometriumbiopsyThefirsttimeisinthemiddlepretreatmentcycleThesecondtimeisthesixtiethdayinthetreatmentcycleThethirdtimeisthehundredandtwentiethdayinthetreatmentcycleEndometriamhaveb

7、eenevaluatedforhistologyandimmunolocalizationofoestrogenreceptors(ER)，progesteronereceptors(PR)Results：Inthetreatmentcycle，women’Sliverfunctionkidneyfunction，fatmetabolismandseruInglucosearenormalNoseveresidee掃FectInthet