天然黃酮類(lèi)磷脂復(fù)合物的制備及性質(zhì)研究.pdf

1、武漢理工大學(xué)碩士學(xué)位論文天然黃酮類(lèi)磷脂復(fù)合物的制備及性質(zhì)研究姓名：唐傳球申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：王繼勇20050501AbstractFlavonoidsisaclassofsubstancesverywidelydistributedinthevegetalkingdomFlavonoidsareknowntopossessanumberofrecognizedpharmacologicalpropertiesamo

2、ngwhicharetheanti—inflammatory，antispasmodicantihistaminicperipheralvasodilatory，plateletantiaggregating，vasoprotectorintermsofalteredcapillaryfragilityandpermeabiliytThecompoundsofflavonoidswithphospholipidsareperfectly

3、absorbedthroughoraladinistrationandincreasethetherapeuticeffectivenessoftheflavonoidsbothbyoralandparenteralortopicaladmnistration，thankstotheirlipophilecharacterInpresentstrdyflavonoids’Scomplexispreparedwithphospholipi

4、dTheresearchfocusesontheformationmechanismofflavonoid—phospholipidcomplexanditschemicalandbiologicalcharacteristicsInordertoprovideascientificbasisforthedevelopmentandapplicationofthisstudyaseriesofexperimentsbavebeendon

5、einthepreparation，thestructureconfirmation，theformationmechanism，thephysico—chemicalpropertyHowever，aseverelimitationexistsandisimputabletothepoororverypoorabsorptionoftheseactiveconstituentswhenadministeredperOS，orbytop

6、icalapplicationNewattemptsaremadetotheresearchofthereactionconditionsofflavonoidphospholipidcomplex，andareasonablecriterionofaccurateevaluationisestablished，bywhichsuchfactorsastemperature，theratioofflavonoidtophospholip

7、idandtheconcentrationofreactantsareexaminedTheobtainedcomplexisconfirmedbynuclearmagneticresonance(NMR)spectroscopyandInfrared(IR)spectroscopyInIRspectrumofthecomplex，thepeaksofflavonoidmovetohighwavenumberTherehasbeenam

8、arkedchangeoftheNMRsignalsofthefunctionalgroupsinvolvedintheformationThesignalsbelongingtoflavonoidareSObroadenedthattheycouldn’tbedetectedAsfarasphospholipidisconcemedthereisamoderatebroadeningofallsignalsandessientiall