DAPK1、RARβ及APC在甲狀腺癌中的蛋白表達及意義.pdf

1、新疆醫(yī)科大學碩士學位論文DAPK1、RARβ及APC在甲狀腺癌中的蛋白表達及意義姓名：武爽申請學位級別：碩士專業(yè)：醫(yī)學遺傳學指導教師：夏米西努爾·伊力克2011-04新疆醫(yī)科大學碩士學位論文 2Expression and significance of DAPK1、RARßand APC protein in thyroid carcinoma Postgraduate student: Wu

2、 Shuang Supervisor: Prof. Xiamixinuer· Yilike Abstract Objective: To evaluate the expression and clinical significance of DAPK1、RARß and APC in thyroid carcinoma.Methods: 1. In this study, three k

3、inds of tumor suppressor genes and abnormal gland cancer methylation genes such as DAPK1、RARß and APC,are selected,which have already been confirmed. 2. Immunohistochemical stain was used to de

4、termine the protein expression of these genes in 63 cases of thyroid cancers, 21 cases of thyroid adenoma,13 cases of hashimoto’ s thyroiditis,10 cases of nodular goiter and 12 cases of normal

5、 thyroid tissue. Results: 1. The variance of DAPK1's protein expression has statistical significance in the thyroid gland various pathological tissues (P nodular goiter （60%， 6 /10） > hashimo

6、to’ s thyroiditis （53.8%， 7 /13） > thyroid adenoma （47.6%， 10/21） > thyroid cancer （28.6%， 18/63） ； 2. The variance of RARß 's protein expression has statistical significance in the thyroid

7、 gland various pathological tissues (P 0.05),and from total not significant change tendency ；4. There are statistical significance that DAPK1 and RARß is to clinical stage and lymphnode meta

8、stasis in thyroid cancer；5. The protein expression of DAPK1、RARßand APC are nothing to do with age, gender and ethnic （P >0.05） ； 6.The expression of DAPK1 in thyroid cancer was positively

9、 correlated with the expression of APC（r =0.445，0.4＜r＜0.7，P =0.000，P <0.05）.Conclusion: 1. It suggests that the expression of DAPK1 is correlated with the carcinogenesis， progression， infiltration

10、 and lymph node metastasis of thyroid carcinoma，it can serves as important indicators for predicting lymph node metastasis in thyroid carcinoma. 2. It suggests that the expression of RARßis

11、 correlated with the lymph node metastasis of thyroid carcinoma.3. The variance of APC's protein expression has not significant change tendency, the value of becoming diagnosis mark of thyro