凋膜止崩乳膏對(duì)子宮內(nèi)膜癌前病變(EH)抑癌基因FHIT表達(dá)的影響.pdf

1、陜西中醫(yī)藥大學(xué)學(xué)位論文原創(chuàng)性聲明及使用授權(quán)聲明學(xué)位論文原創(chuàng)性聲明本人鄭重聲明：所呈交的學(xué)位論文，是個(gè)人在導(dǎo)師的指導(dǎo)下，獨(dú)立進(jìn)行研究工作所取得的成果，無(wú)抄襲及編造行為。除文中已經(jīng)特別加以注明引用的內(nèi)容外，本論文不含任何其他個(gè)人或集體已經(jīng)發(fā)表或撰寫過(guò)的作品成果。對(duì)本文的研究做出重要貢獻(xiàn)的個(gè)人和集體，均己在文中以明確方式標(biāo)明并致謝。本人完全意識(shí)到本聲明的法律結(jié)果并由本人所承擔(dān)的法律責(zé)任。學(xué)位論文作者簽名(需親筆日期：_l苫年關(guān)于學(xué)位論文使用授

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3、師簽名(需親筆)二獺日期：v心年女月y日PromotingBIoodCircuIationandRemovingBIoodStasiSTargetedInterventiononEndometriaIPrecancerousLesion(EH)CorreIationEffectofAntI_oncogeneFHITProteinExpressionAbstractObjective：FHITisatumorsuppressorgeneT

4、evealthemolecularmechanismofDiaomoZhibengCreamintreatingendometrialprecancerouslesionsbydetectingdifferenceofFHITexpressioninboththeDiaomoZhibengCreamgroupandnon—DiaomoZhibengCreamgroupMethods：From2012to2015，30casesinthe

5、AffiliatedHospitalofShaanxiUniversityofChineseMedicine(bloodstasistypebasedonTCMdifferentiation，Bultrasoundsuggestingendometrialthickness1cmnovaginalbleeding，endometrialpathologyconsistentwithatypicalhyperplasia)，aged27—

6、52yearsoldwithnofertilityrequirementsareselectedAfterpatients’consensus，3mlofDiaomoZhibengCreamisinjectedintotheuterinecavity(containingrawdrug：99／m1)priortothefollowing48一hoursobservationEndometrialtissuesbeforeandafter

7、medicationareobtainedasexperimentalspecimenThechangeofmRNAexpressionofFHITgeneinbothendometrialtissuespecimeniSdetectedbyusingRT—PCRdetectionmethod：thedifferencesofFHITgeneproteinexpressioninendometrialtissuearedetectedb

8、yimunohistochemistrySABCmethodandWesternblotResults：immunohistochemistryFHITinEHgroupandDiaomoZhibengCreaIIIgroupwitnesstheexpression，withthelattergroupshowingmorepositireexpression：InPCR—CT，DiaomoZhibenggroupdemonstrate

9、sobviousFHITmRNAexpressionincomparisonwiththeEHincreaseofFHITexpressioninCreamgroup：Inwestern—blot，thereisangroupTheDiaomoZhibengCreamcansignificantly1ncreaseexpressionofFItITinendometrialhyperplasia，withstatisticallysig

10、nificantdifferencebetweenthetwogroups(PO01)Conclusion：1DiaomoZhibengCreamcanincreasetheexpressionoffragi1ehistidinetriad，regulatetheexpressionofdownstreamgenes，inhibitglandproliferationandcellproliferationandtheformation