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1、中國農業(yè)大學博士學位論文牛流行性白血病分子病理及其應用研究姓名：龍塔申請學位級別：博士專業(yè)：預防獸醫(yī)指導教師：佘銳萍潘耀謙20041201AbstractEnzooticbovineleukemia(EBL)isaninfectiousneoplasmcausedbybovineleukemiavirus(BLV)ThisdiseaseisfoundinallcountriesofworldwhichraisecowsThereisas

2、ernmpositiveratefrom30％to50％inSOl／lecattlegroupsinourcountryItcausesthreateningforraisingcattleinChinaUptonowthereisnomethodtocontrolandtreatthisdiseaseTheaimofstudyonappearanceofEBLismainlycentralizedonBLVTheknowledgeof

3、genesexpressionisafewinthefunctionofEBLandaspectsindiagnosisandtreatmentThisstudythatobservedtheexpressionanddistributionof4apoptoticfactors，relationapoptoticfactorwithapoptosis，changesofTandBsubgroup，andchangesofmolecul

4、arpathologyin14cowssufferingfromenzooticbovineleucosisfromseveralresideswasdetectedbyhistochemistryTUNELtechnologyimmunefluorescentflowcytometryandsoonTheaimofthisexperimentsuppliestheoreticbasisforpreventiveandtherapyof

5、EBL，andconsuRdatesforTlymphoidcellleucosisofhumanbeingTheresuRsweredescribedinthefollowing，Theneoplasmlesionswerefoundinalllyrephnodesofbody(especiallyinnecksuperficiallyrephnode，mesenterylymphnodeanddiaphragmlymphnode)a

6、ndalotoforgans(cgheart，stomachandkidneysandsoon)MicroscopicallythepervasionoftumorcellstotheorgansandtissueswasfoundthroughthelymphvesselsandbloodvesselsThesuggestionswereputforwardthatitshouldgettostrengtheninspectionin

7、EBL，treatasusinginindustryandnoeatingforslaughteredbedywithtumorsinalllymphnodesandorgansThepositivecellsexpressionofP53hadanimportantrelationtotheappearanceofEBLBcellswithP53mutationstrainmightbeatargetcelltoformattumor

8、sBaxandCaspase3hadahighexpressionintumorcellswithmoredifferentiationandapositiverelationtotumorcellapoptosisfP001)ThepositiveexpressionintensityofBcl2hadarelationtodegreeoftulnorcelldepravationandhadanegativerelationtotu

9、morcellapeptosisrPO01)ThisfindingmightofferanewwaytostudymolecularmechanismofdevelopmentintumorcellsandanewtheoryfordiagnosisandgenestreatmentofEBLinclinicThisstudyindicatedthat14caseshadacharacteristicoflinesBandruinere

10、elloriginfromBlacellsCDl9，CD20，CD45RAandCD45RBwerethereliablesuperficialsignsTheabnormalityofTcellswasfoundinearlewithEBLOwingtolossequilibriumofCD4cellandCD8cellandreducecounteractiontotmnorcells，theruinerappearedinbody

11、Therefore，reinforcingbreedingandheighteningresistibilityhaveimportantmeansinpreventingEBLThisstudyshowedthatthetumorcellsmighthaveabilitytosecreteTNFa，VEGFandCTTheyhadahigherexpressiveratethantumorsidewardtissuesandhadas

12、ignificantlystatisticdifferencebetweenbothtumortissuesandtumorsidewardtissuesrP001)AmongthempositiveexpressionratioofBEGFwas786％andTNF—awas429％InvirtueofVEBFmoreexpressionnewvesselsintumortissuescouldgrowandledtotumorcel

13、linfiltrationtoalotoftissuesTheresultsindicatedthatlevelofVEGFandCTintumortissuesmightmakeasasigntodiagnosisofEBLVEGFmightalsomakeavaluablejndexofrecrudesceandtreatmentoftumorinclinicTheformationofantivesselshadaimportan

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