含烷氧基的氰基丙烯酸酯、氰基丙烯酰胺及α-氨基膦酸酯衍生物的合成與生物活性研究.pdf

1、貴州大學(xué)碩士學(xué)位論文含烷氧基的氰基丙烯酸酯、氰基丙烯酰胺及α氨基膦酸酯衍生物的合成與生物活性研究姓名：龍寧申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：宋寶安20080501蕤建大學(xué)2008弱碩士瓣究生華娩論文AbstractCyanoacrylate，animportantclassofbioactivecompound，iswidelyappliedinagrochemistryInourpreviousworkcyanoacrylat

2、escontainingpyridyl，chiratanilinemoiety，phosphonylmoiety，etal，havebeensynthesized，andtheiractivitieswereevaluated。TheresulteshowsthatthesecompoundspossesshighantiviraiactivitiesIn2005，BingQingxiao，whichshowedaremarkablea

3、ctivityagainsttobaccomosaicviruswasdevelopedasakindofantiTMVagant。Inordertoselectcyanoacrylatesderivativeswithhighbioactivity，alkoxyl，amineand瑾aminophosphonatemoietieswereintroducedintothestructureofcyanoacrylate42titlec

4、ompoundsweresynthesized，amongwhich12werealkoxylcyanoacrylates6wereaminecyanoacrylatesand24wereaaminophosphonatecyanoacrylatesThestructureofallcompoundswasconfirmedby1HNMR，13CNMRIRandelementalanalysisThecrystalstructureof

5、compoundlIIvwasconfirmedbYXraydiffraction。X—rayintensitydataoflIIvlistedasfollowings：thecrystalbelongstoorthorhombiccrystalsystem，spacegroupisP2(1)／n口=lO4331(14)nm，6=123900(16)nm，c=210677(15)nm，a=90。000。，妒91193“rz90000。，

6、Z=26，V=27370(5)nm3，￡f=1682mg／m3，伊191，2500。，l尸0961mm一，F(xiàn)(000)=1378，thefinalleast—squarescyclegivesR00558，刪1610。Tooptimizethereactionconditions，thesynthesisofcompounds111werecarriedoutunderseveralconditions，suchasultrasonic

7、irradiation，microwaveirradiationandionliquidThemicrowaveirradiationcallimprovethesynthesisThemoreviableconditionWasobtainedasfollowing：undermicrowaveirradiationof010kw689kPaat100℃for25minutes，compoundsIllgandllliweresynt

8、hesizedwithhighyields878％and83霹％，respectivelyComparedtOtheclassicalmethod，thepresentoneoffersseveraladvantagesincludingenvironmentalfriendgreenerfasterreactionrates，fewerbyproducts，andhiglleryields。Theresultofbioassaysho