Bcl-2、Bad蛋白表達與乳腺癌的相關(guān)性研究.pdf

1、山西醫(yī)科大學碩士學位論文Bcl2、Bad蛋白表達與乳腺癌的相關(guān)性研究姓名：王曉薇申請學位級別：碩士專業(yè)：普通外科指導教師：郭炳麟2003.5.19!塑查竺!!!!!!圭竺竺竺蘭英文摘要Researchonthecorrelationofgenesbcl2andbadinbreastcarcinomaAbstractobjectiveTbdetemineapoptosisregulatinggenebcl一2andbadinmaligna

2、nttrallsfbnllationofbreastcajlceraJlditsprecancerouslesions，andbcl一2andbadcorrelatingwithestrogenreceptor(ER)andprogesteronereceptor(PR)，withlymphnodesmetastasisofbreastcanceLMethodsByimmunohistochemicalmethod，theexpress

3、ionofbcl2aIldbadgenewereobservedin8casesofnormalbreasttissues19casesofbreasthyerplasia，20caSesofbreastatypical，48casesofbreastcancerinsitus，andtesttheexpressionofER，PRandbcl—2，badinthebreaStcanceLEightnornlalbrcasttissue

4、swereusedcontr01ResultsThebcl2genewaslOO％positiveeXpressioninthe8casesofnomlalbreasttissuesatld19casesofhyprepl船iaAstatisticallysignificationwasfoundbetweenpositiverate5833％ofbcl—2inbreastcancera11d85O％ofatypical(X2=337P

5、O05)ThepositiVerateofbadoncopmteinisoflowertendencytIlanbcl一2ofeverygroup：875％inno姍al，842％inhypelplaSia，550％inatypical，479％inbreastcancer，respectivelyTherewassignificantdiffcrencebetweenpos“iverateofbcl2andbadineachgroup

6、(x2=2305PO00l，x2=1129P001)InthebreastcancergmupthepositiVemteofbcl2aIldbadoncoproteinisdecreaSingwitIlthelowingdegreeofdi丹brcntiationoftIlIlloLThepositiverateofERandPRhaspositiverel砒ion、vimtheeXpressionofbcl一2aJldbadConc