大劑量岷當(dāng)歸配伍川芎對腦缺血再灌注損傷大鼠腦組織中ICAM-l、IL-1β和COX-2mRNA的影響.pdf

1、分類號：密級：碩士研究生學(xué)位論文論文題目（中文）大劑量岷當(dāng)歸配伍川芎劑量岷當(dāng)歸配伍川芎對腦缺血再灌注腦缺血再灌注損傷損傷大鼠大鼠腦組織中腦組織中ICAMICAMl、ILIL1β和β和COXCOX2mRNA2mRNA的影響的影響論文題目（外文）EffectEffectofofalargedosalargedoseofofAngelicasinensisAngelicasinensisChuanxiongonChuanxiongontheE

2、xpressionoftheExpressionofICAMICAMl、ILIL1β、β、COXCOX2mRNAinBrainmRNAinBrainTissuesTissuesofofCerebralCerebralischemiaischemiaReperfusioninjuryeperfusioninjuryRatRat研究生姓名左毅學(xué)科、專業(yè)方劑學(xué)方劑學(xué)研究方向心腦血管疾病治法與方劑的實(shí)驗(yàn)及臨床研究心腦血管疾病治法與方劑的實(shí)驗(yàn)及臨

3、床研究導(dǎo)師姓名、職稱李妍怡教授李妍怡教授論文工作起止年月20112011年3月至20122012年3月論文提交日期20122012年3月論文答辯日期20122012年5月學(xué)位授予日期20122012年6月目錄目錄中文摘要..............................................................................................................

4、........1Abstract...............................................................................................................................2前言.........................................................................

5、...........................................................5一、立題依據(jù)....................................................................................................................71.祖國醫(yī)學(xué)對腦缺血再灌注損傷的認(rèn)識及研究現(xiàn)狀..............

6、...............................71.1中醫(yī)對“中風(fēng)”病名及病位的認(rèn)識..........................................................71.2中醫(yī)對“中風(fēng)”病因病機(jī)的認(rèn)識..............................................................71.3中醫(yī)藥治療“中風(fēng)”病的研究...............

7、...................................................92.現(xiàn)代醫(yī)學(xué)對腦缺血再灌注損傷的認(rèn)識...............................................................122.1自由基與腦缺血再灌注損傷....................................................................12

8、2.2炎癥反應(yīng)與腦缺血再灌注損傷...............................................................132.3細(xì)胞內(nèi)鈣離子超載與腦缺血再灌注損傷..............................................132.4興奮性氨基酸與腦缺血再灌注損傷.....................................................

9、..142.5細(xì)胞凋亡與腦缺血再灌注損傷...............................................................143腦缺血再灌注損傷模型研究的進(jìn)展................................................................153.1動物的選擇.............................................

10、...................................................153.2局灶性腦缺血模型....................................................................................153.3全腦缺血模型.............................................................

11、...............................16二、實(shí)驗(yàn)研究..................................................................................................................181.實(shí)驗(yàn)材料...........................................................

12、....................................................181.1實(shí)驗(yàn)動物....................................................................................................181.2實(shí)驗(yàn)藥品..................................................

13、..................................................181.3主要實(shí)驗(yàn)儀器及試劑................................................................................182.實(shí)驗(yàn)方法....................................................................

14、...........................................182.1動物分組....................................................................................................182.2給藥方法...........................................................

15、.........................................192.3模型建立....................................................................................................192.4模型評分標(biāo)準(zhǔn)...........................................................