苦皮藤根皮的化學(xué)成分研究.pdf

1、苦皮藤(Celastrus angulatus Max.)是衛(wèi)矛科南蛇藤屬的一種多年生灌木,廣泛分布在我國(guó)長(zhǎng)江和黃河流域的丘陵淺山區(qū)。作為傳統(tǒng)的殺蟲植物,苦皮藤根皮具有殺蟲活性,可以防治某些蔬菜害蟲。為充分利用我國(guó)的植物資源,進(jìn)一步開發(fā)苦皮藤的藥用部位,尋找苦皮藤新的活性成分,我們系統(tǒng)研究了苦皮藤根皮的化學(xué)成分。
　　 應(yīng)用多種現(xiàn)代分離純化方法和技術(shù),從苦皮藤根皮的乙醇提取物中分離得到17個(gè)化合物,通過各種波譜技術(shù),包括:1H-

2、NMR、13C-NMR、EI-MS、1H-1H COSY、HSQC、HMBC、NOESY等鑒定了其中15個(gè)化合物,成分鑒定為:β-谷甾醇(β-sitosterol,G-01)；1β,2β-二乙酰氧基-8a,13-二異丁酰氧基-9β-苯甲酰基-4a,6a-二羥基-β-二氫沉香呋喃(1β,2β-diacetoxy-8a,13-diisobutanoyloxy-9β-benzoyloxy-4a,6a-dihydroxy-β-dihydroag

3、arofuran,G-02)；1β,2β,6a-乙酰氧基-4a-羥基-8β,13-二異丁酰氧基-9a-苯甲酰氧基-β-二氫沉香呋喃(1β,2β,6a-triacetoxy-8β,13-diisobutanoyloxy-9a-benzoyloxy-4a-hydroxy-β-dihydroagarofuran,G-03)；1β,2β,6a-三乙酰氧基-4a-羥基-8β-異丁酰氧基-9a-苯甲酰氧基-13-異戊酰氧基-β-二氫沉香呋喃(1β,

4、2β,6a-triacetoxy-8β-isobutanoyloxy-9a-benzoyloxy-13-(a-methyl)-butanoyloxy-4a-hydroxy-β-dihydroagarof-uran,G-04)；1β-異煙酰氧基-2β,6a-二乙酰氧基-4a-羥基-8β,13-二異丁酰氧基-9a-呋喃酰氧基-β-二氫沉香呋喃(1β-picolinoyloxy-2β,6a-diacetoxy-8β,13-diisobutan

5、oyloxy-9a-furanoyloxy-4a-hydroxy-β-dihydroagarofuran,G-05)；1β-異煙酰氧基-2β,6a-二乙酰氧基-4a-羥基-8β,13-二異丁酰氧基-9a-苯甲酰氧基-β-二氫沉香呋哺(1β-picolinoyloxy-2β,6a-diacetoxy-8β,13-diisobutanoyloxy-9a-benzoyloxy-4a-hydroxy-β-dihydroagarofuran,G-

6、06)；1β,6a-二乙酰氧基-2β-煙酰氧基-4a-羥基-8β,13-二異丁酰氧基-9a-苯甲酰氧基-β-二氫沉香呋哺(1β,6a-diacetoxy-2β-nicotinoyloxy-8β,13-diisobutanoyloxy-9a-benzoyloxy-4a-hydroxy-β-dihydroagarofuran,G-07)；1β,2β,6a-三乙酰氧基-4a-羥基-8β,13-二異戊酰氧基-9a-.苯甲酰氧基-β-二氫沉香呋喃

7、(1β,2β,6a-triacetoxy-8β,13-di(a-methyl)一butanoyloxy-9a-benzoyloxy-4a-hydroxy-β-dihydroagarofuran,G-08)；槲皮素(quercetin,G-09):兒茶素(catechin,G-10)；表兒茶素(epicatechin,G-11)；β-胡蘿卜苷(β-daucosterol,G-12)；異槲皮苷(isoquercitrin,G-13)；間苯二