大腸上皮惡性轉(zhuǎn)化不同階段中Fas-Fasl表達(dá)及在凋亡逃逸中的意義.pdf

1、天津醫(yī)科大學(xué)碩士學(xué)位論文大腸上皮惡性轉(zhuǎn)化不同階段中FasFasl表達(dá)及在凋亡逃逸中的意義姓名：王展宏申請學(xué)位級別：碩士專業(yè)：病理學(xué)指導(dǎo)教師：孫保存2001.5.1天津醫(yī)科大學(xué)碩士學(xué)位論文死亡信號，形成“Fas抵抗”，并因此抑制癌細(xì)抗”機(jī)制的配合下，關(guān)健詞t大腸腫瘤，使大腸癌最終形成及進(jìn)展“Fas反擊”在“Fas抵細(xì)胞凋亡，F(xiàn)as基因，腫瘤浸潤淋巴細(xì)胞Abstractobjeetlve：Recentlyaprevalentimmuneev

2、asionmechanismofcancerFascounterattackiselucidatedbysomeoverseasscientistsThisarticleattemptstoexplorethemolecularmechanismunderlyingtheFascounterattackbyobservingtheexpressionofFasandFasl，CD20andCD45ROantigens，P53protei

3、nandapoptosisandfurtheranalysingtherelationshipsbetweenthemMethods：Usinginsituhybridization，immunohistochemistryandTUNELtechniqes，weexaminedanumberofparaffinembededtissuesincluding37CageSoflargeintestinaladenocarcinomas2

4、6e&sesofmalignantlytransformedadenomas，30casesoftubulovillousadenomas，and24casesoftubularadenomasforFasmRNA，F(xiàn)aslmRNA，CD20antigen，CD45ROantigen，P53proteinandDNAfragment6casesofnortumormucosasarcusedascontrolgroupResult：Wi

5、ththeprogressionofthemalignanttransformation，F(xiàn)asmRNAexpressionsincreaseslightlyinbenignadenomas，andthendecreasesignificantlyinmalignantdiseasesFaslmRNAexpressionsshowallincreasingtendencyApoptoticlymphocytedensitieshavea

6、nincreasingtendencytooP53proteinshowsthelowestexpressioninnontumormucogas，aslightincreaseiabenignadensmas，butthehighestexpressioninmalignantdiseasesApoptoticeelldensitiesincreaseinbenigntumorsandthendecreaseinmalignanttu

7、morsBandTcelldensitiesshowsignificantdecreasesinmalignantdiseasesNegativecorrelationsarefoundinmalignantdiseases(rI=加559，p0001，inadenocareinomas，andr一0461，p005inmalignantareasofadenomasrespectively)betweenF船lexpressionsa