1、甲型肝炎減毒活疫苗與滅活疫苗免疫原性的比較2、孕婦及其母親HBV標(biāo)志物的配對研究3、細(xì)菌性痢疾的發(fā)病率監(jiān)測與疾病負(fù)擔(dān)研究.pdf

1、Abstract We conducted a study to compare the immune response induced by a live attenuated hepatitis A vaccine(HAV vaccine).26 children received 2 doses regimens of live attenuated HAV vaccine and 33 susceptible children

2、received inactivated HAV vaccine.The children were bled at months 1,6,7,12 and 24.Anti-HAV and IgG subclass profile were assessed.In both the live and the inactivated vaccinated group,the geometric mean titer(GMT) of ant

3、i-HAV,peaked 7 months after the initial dose and declined during the following months.The GMTs in children receiving live attenuated HAV vaccine was 19,46,1306,448,217mIU/mL at months 1,6,7,12 and 24 respectively. In chi

4、ldren who received the inactivated vaccine the GMTs were 21,61,2615,1062mIU/mL.Both vaccines produced good secondary immune response.The lgG subclass profile in inactivated and live attenuated vaccine group at months 1,7

5、 and 24 were highly restricted to IgG1 and IgG3.Thus both vaccines may be highly effective in virus neutralization.乙肝病毒在人群中的傳播方式有母嬰傳播和水平傳播.隨著乙肝病毒抗原抗體系統(tǒng)的發(fā)現(xiàn),70年代后世界各地相繼報道了乙肝病毒的母嬰傳播.研究表明乙肝病毒母嬰傳播率在亞洲最高,非洲中等,歐美最低,分別為30﹪~70﹪、2

6、0﹪~30﹪、10﹪左右<'[1,2,3]>.母嬰傳播是中國乙肝病毒傳播的重要途徑.國內(nèi)外學(xué)者均報道孕婦乙肝表面抗原滴度、e抗原及其血清乙肝病毒DNA(HBV-NDA)水平與母嬰傳播的發(fā)生概率正相關(guān)<'[4,5,6,7]>,即母嬰傳播的親代具有相對較高的病毒含量,而至今未見對孕婦及其親代血清病毒含量的相關(guān)性進(jìn)行研究.該次研究旨在探討高滴度血清病毒含量的孕婦的母親是否也具有較高的血清病毒含量以及兩者C基因序列的同源性.結(jié)合已有的大量的乙型

7、肝炎母嬰傳播的文獻(xiàn)及我們既往的研究結(jié)果,對孕婦及其親代所攜帶的病毒的相關(guān)性進(jìn)行研究.感染性腹瀉(infection diarrhoea)是由病原微生物及其產(chǎn)物或寄生蟲所引起的以腹瀉為主的一組急性腸道傳染病.感染性腹瀉的病原,目前已知有50余種,其中,細(xì)菌性痢疾占感染性腹瀉的主要部分.在中國,隨著經(jīng)濟(jì)的發(fā)展,生活水平的提高,雖然疾病譜有了明顯的改變,慢性病構(gòu)成比逐步上升,傳染病發(fā)病構(gòu)成比下降,但是并沒有得到根本的控制.感染性腹瀉及其中的細(xì)

8、菌性痢疾仍然是危害人民健康的主要疾病之一<'[1,2,3]>.1999年全國疾病監(jiān)測數(shù)據(jù)顯示<'[4]>,在全死因順位中,感染性疾病排名第5位,而痢疾則占感染性疾病死因順位的第4位.1999年全國傳染病報告數(shù)據(jù),痢疾發(fā)病率為48.3/10萬,占全國26種甲乙類傳染病發(fā)病率順位的第2位,同時有關(guān)部門認(rèn)為細(xì)菌性痢疾存在著較高的漏報率<'[5]>.因此,對細(xì)菌性痢疾發(fā)病情況進(jìn)行監(jiān)測,以獲取相對準(zhǔn)確的流行病學(xué)及病原學(xué)數(shù)據(jù),估計人群發(fā)病率從而評估