villin和MUC2在結(jié)腸腺癌發(fā)生、發(fā)展中的表達及意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文villin和MUC2在結(jié)腸腺癌發(fā)生、發(fā)展中的表達及意義姓名：喬星申請學(xué)位級別：碩士專業(yè)：病理學(xué)指導(dǎo)教師：李士瑛梁建芳20060515山西醫(yī)科大學(xué)碩士學(xué)位論文ExpressionofvillinandMUC2inCarcinogenesisandProgessionofColonCarcinomaandTheirClinicalSignificanceAbstractobjective：Tostudytheexp

2、ressionofvillinandMUC2inthestagesofcarcinogenesisandprogessionincoloncarcinomaandtofindouttherelationshipbetweentheexpressionlevelandclinieo—pathologicalcharacteristicsandbetweentheexpressionofthemandthetumorigenesisofco

3、lonadenomasandexploretheirrelationshipMethods：DetectingvillinandMUC2proteinsbyusingPicTureTMimmunohistochemicalstainingtechniquein40resectedcolonmucosa，20colonadenoma(13lowermoderatedysplasiaand7severedysplasia)and40colo

4、nadenocareinomamucosaand40thematchingperi—carcinomamucosaResults：(1)Theresultsshowedthatvillinpositivestainingwasfoundincellmembranewithbrushbordermicrovilliandintheapicalcytoplasm，adjacenttothevilluspartlybutnegativeing

5、obletcellTherewandifferentdegreeheterogenecityintheexpressionofvilllinincoloncarcinomaandcolonadenomaFortheresectedcolonmucosacolonadenomaandcolonadenocarcinomathepositiveratesofexpressionofvillinwere90O％、750％、50O％respec

6、tivelyandthedifferenceamongthesegroupsweresignificant(P005)butthedifferenceweresignificantbetweenresectedcolonmucosaandseveredysplasiamucosarP005)(2)TheresultsshowedthatMUC2positivestainingwasfoundintheperinuclearcytopla

7、smofcellswithagobletcelltypethecaandwithapicalmucousdropletsThereWasdifferentdegreeheterogenecityintheexpressionofMUC2incoloncarcinomaandcolonadenomaFortheresectedcolonmucosa，colonadenomaandcolonadenocarcinoma，thepositiv