吡咯烷硫酮衍生物的合成及結構表征.pdf

1、南京理工大學博士學位論文吡咯烷硫酮衍生物的合成及結構表征姓名：胡炳成申請學位級別：博士專業(yè)：應用化學指導教師：呂春緒20040901ABSTRACTNaturalcyclictetrapyrroles，whichinvolveporphyrins，chlorins，bacteriochlorins，isobacteriochlorins，highersaturatedhydroporphyrinsandcoffins，belongtoa

2、kindoflivingsubstanceswithmanifoldbiofunctionsTheresearchontheirsynthesisandapplicationispresentlyanimportantstudycontentandhotspotsofthechemistryofnaturalproducts。Inthisdissertation，thebasisof‘‘31”methodtosynthesizethec

3、yclictetrapyrroleswassummarizedthroughtheanalysisandcomparisontovarioussynthesismethodsofchlorins，andthedesignprincipleandtrendofthephotosynthesismodelsystemsandthenewgenerationphotosensitizerswereproposedonthebasisofthe

4、analysistotheactingprocessandmechanismofthephotosynthesisandphotodynamictherapyThetotalsynthesiswaysoftheehlorinmodelchlorophylla(belongstochlorins)andthetotyporphinmodel(belongstobacteriochlorins)weredesignedaccordingto

5、the“31”synthesismethodThesynthesisofseveralpyrrolidthionederivativeswerestudied，suchasthering—Abuildingblockoftheehlorinmodel—_2一cyano2，3，3trimethyl5thioxo—pyrrolidine，thering—Dbuildingblockofchlorophylla—一2cyano一2，3dime

6、thyl3一(Nbenzylmethanamido)oxymethyl4一(2’methoxy—carbonyl)ethyl5thioxo—pyrrolidineandthering—Abuildingblockofthetolyporphinmodel—五cyano一23一dimethyl一3一methoxycarbonylmethyl5一thioxo—pyrrolidineThestructuresofthesyntheticpro

7、ductswerecharacterizedbyelementalanalysis，ultravioletvisible(UVvis)，infrared(IR)，1Hand”Cnuclearmagneticresonance(NMR)andmassspectra(MS)Theresultscametothefollowingconclusions：thestructuresandperformanceindexesoftheproduc

8、tsconformedtothedesignrequirement，thesynthesiswaysofthetargetcompoundswerebriefandhadgoodselectivity；thesynthesiswayofthering—Abuildingblockofthechlorinmodelpossessedveryhighpracticalvalueforitwascomposedofonlysixsteprea

9、ctionsandtheyieldofeveryreactionreachedmorethan80％：thetolyporphinmodelreflectedthestructuralcharacteristicofnaturaltolyporphincompoundsandthesynthesisdesignofitsring—Abuildingblockwasnovel，practicalandeffectiveKeywords：p