腦出血患者血栓調(diào)節(jié)蛋白動態(tài)變化研究.pdf

1、浙江大學碩士學位論文腦出血患者血栓調(diào)節(jié)蛋白動態(tài)變化研究姓名：陳文珍申請學位級別：碩士專業(yè)：神經(jīng)病學指導教師：鄭錦志20050325浙江天學碗士學位論吏[Abstract1Background：Thrombomodulin(TM)isamonochainglucoproteinexistsonendothe】a1cel1membraneTMissynthesizedbyvasculatendotheliocyteandplacentalt

2、rophocyteItsgenelocatesinchromosomesofnumber20E—smoneta]founditin1981andthenseparatedthisactjvemassSUCCOssfullyat1982andnameditthrombomodulinFromthenon，peoplefoundOULt／at7rMdjstFibuteddiffuselYonendotheliaofaFteresveins，

3、capi1laryvesselsand1ymphatics，especiallYonthatoftissuesof1ung，kidneyandplacentaTMplayaimportantroleinblcodanticoagulantmeehanismItcanmakeanticoagu]antandfibrin01vtjcativefunctionsthroughtaooelerationthrombaseactivingprot

4、einCandmakediFeetantjcoagulanteffect1hroughinhihitorythrombasesactivationBecauseTMisspecificdistributiononvascularendothelia，soitcanbecomeamolecularsignofvesselwall1esionsandangiomaItoffersanewwayincliniconmeasurementofP

5、Cactivation，diagnosisandtherapyofthrombosis，diagnosisofangiomaandearlymonitoringvesselwalllesionAfterstudyonTMchangeincerebralvasculardiseases，peoplefoundoutthatTMasasignofendothelial1esionsWOUldrisesignjficarltlYnomatte

6、rincerebralinfarctionorcerebralhemorrhage，inacutestageorrestorationstage，butdymanicobservationonTMindjFfeFenLDerjodsofc：erebralhemorrhagestillhaven’tbeendoneandmeaningofTM’sdynamicvatiationincerebralhemorrhageremainsunkn

7、ownSomvstudvisondynamicvatiationofTMincerebralhemorrhageObiective：Toobservethedynamicvatiationofthrombomodulinindifferentperiodeofpatientswithcerebralhemorrhage，andtoprobethechangeofvasculatendotheliallesionindifferentpe

8、riodsofcerebralhemorrhageandtheeffectofblcodcoagulationmechanismMethods：Thethrombomodulin1evelsof53casescerebralhemorrhageswereNearsuredrespecilvelvat1～3dand10～14din25casesandonlyatl～3dinanother28casesbymeansofELISAResul

9、ts：LevelsofTMin25patientswithcerebralhemorrhage1～3dwerelowerthanthoseof10～14dLevelsofTMinanother28patientSgroupwerehigherthanpreviOUSgroupthoseoflO～14dandl～3dLevelsofall1～3d(53cases)wereJowerthanthoseof1014dButa11ofthese

10、differenceshavenostatisticalsignificanceConclusion：Leve】sof’TMtnpatientswithcerebralhemorrhagehavenosignificantvallietvbetweenthoseof1～3dand10～14dEndothelialdamagecat]sedbycerebralhemorrhagecentinuesonmorethan10～14dConti