來那度胺聯(lián)合地塞米松治療復(fù)發(fā)難治性骨髓瘤的系統(tǒng)評價.pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文來那度胺聯(lián)合地塞米松治療復(fù)發(fā)難治性骨髓瘤的系統(tǒng)評價姓名：王歡申請學(xué)位級別：碩士專業(yè)：內(nèi)科學(xué)指導(dǎo)教師：哈力達亞森200904新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文—2—LenalidoeplusDexamethasonefRelapsedRefractyMultipleMyeloma：SystemicReviewPostgraduate:WangHuanSupervis:Prof.HalidaYa

2、senAbstractObjcetive:Toassesstheefficacysafetyoflenalidoeplusdexamethasone(LD)comparedwithplaceboplusdexamethasone(PD)frelapsedrefractymultiplemyeloma.Methods:WesearchedCochraneLibrary(Issue32008)MEDLINE(withPubmed1966to

3、2008Oct)EMBASE(1984to2005)CBMdisc(1978to2006)CNKI(1979to2008Oct)bycomputerfclinicalstudiesalsosearchedclinicaltrialsregisterfongoingstudiescompletedstudieswithunpublisheddata.Thereferenceofincludedstudiesrelevantsuppleme

4、ntconferenceabstractswerehsearched.Thesearchresultswereextractedthenthequalityofincludedstudieswasassessed.ByRevMan5.0metaanalysiswasusediftherewaslowheterogeneity.Results:Twostudieswith704participantsinallwereincluded.O

5、newashighqualitystudytheotherhadunclearromizationallocationconcealment.TheadverseoutcomeofefficacyofLDsuchasmtalitymtalityduetoprogressionincidenceofprogressivediseasewaslowerthanthoseofPDwhichhadstatisticdifference.Ther

6、ewassignificantlystatisticdifferencebetweenoverallresponserateoftwogroups.TherateofLDwashiger.TheincidenceofthromboticeventneutropeniathrombocytopeniawashigherinLDgroupcomparedwithPD.Theincidenceofdosereductioninterrupti

7、onofLDwasalsohigherthanPD.Theincidenceoftwogroupsincludingotheradverseeventsdeathduetodrugwassimilar.Conclusions:TheefficacyofLDissuperitoPDfrelapsedrefractymultiplemyelomabuttheincidenceofsomedrugadverseeventssuchasthro