有機鹵化鋅與亞胺的不對稱1,3-重排反應(yīng)研究及其在手性敘亮氨酸制備中的應(yīng)用.pdf

1、復(fù)旦大學(xué)碩士學(xué)位論文有機鹵化鋅與亞胺的不對稱1，3重排反應(yīng)研究及其在手性敘亮氨酸制備中的應(yīng)用姓名：鄭巍申請學(xué)位級別：碩士專業(yè)：藥物化學(xué)指導(dǎo)教師：孫遜200905AbstractAbstract0【一aminoacidsexistinawiderangeofproteinsinnatureastheimportantmaterialbasisoflifeNaturala—aminoacidsaregenerallychiralityexc

2、eptGlycine，manyofwhichareprecursorcompoundsofdrugsTherewerealotofasymmetricsynthesisreactionsofchiralaaminoacids，andimineswereoftenusedassubstratetofirstlyformnewaaminoacidsviacyanogroup’SasymmetricadditionoftheC=Nbond，r

3、emovalofNsubstituentandhydrolysisInourpreliminarywork，westudiedtheasymmetricadditionoforganozinchalides、)vithimines，butfoundanovelorganozinchalidesinduced13一migrationoftertbutylfromsulfurtocarboninracemicNtertbutanesulfm

4、yliminoacetatesInthisthesis，wetriedtofurtherstudythisunexpectedrearrangementreactionforpreparationofmaminoacidsandderivativesuSiI培enantiomericallypureimines，discusstheoptimizedconditions，conductaseriesofsubstratesandprop

5、oseareasonablemechanismMoreoverthisrearrangementreactionprovidedanewwayofpreparingenantiomericallypuretertLeucine27newcompoundsinallweresynthesized，andconfirmedbyspectrumanalysisandXrayKeywords：naminoacid，tertLeucine，org