三陰性與非三陰性乳腺癌X線表現(xiàn)的對比研究.pdf

1、青島大學碩士學位論文三陰性與非三陰性乳腺癌X線表現(xiàn)的對比研究姓名：崔春曉申請學位級別：碩士專業(yè)：影像醫(yī)學與核醫(yī)學指導教師：林青20120602Comparisonofmammographybetweentriplenon—triplenegativebreastcancerAbstract㈨v呲2㈣08㈣740㈣91negativeandobjectiveTocomparativeanalysethemammograpllicfindi

2、ngsbetween“triplenegative”breastcancer(thatiSestrogenreceptor【ER】negative，progesteronereceptor【PRlnegative，andhumanepidermalgrowthfactorreceptor2【HER2】negative，TNBClandnontriplenegativebreastcancerandevaluatetherelations

3、hipsofimmunohistochemologicreceptorstatusandmammographicfindingsMaterialsandMethodsW宅identifiedl102womenwhohadbeendiagnosedwithprimarybreastcancerbetweenJanuary2009andDecember2011atasignalhospitalandwhohadundergonemammog

4、raphyatinitialdiagnosisTherearel74casesofTNBC，97casesofER十／PR／HER2，65casesofER卜／PR／HER2，183casesofER／PR／HER2and583casesofER伊R“HEI匕一breastcancerA11ofthelesionswereconfirmedbyhistologicalexaminationsWreretrospectivelyevalu

5、ated也evisibilitymorphologydistributionandsizeofthelesion(massesandcalcifications)andbreastdensityonmammographyof1NBCandtocomparewiththoseofnonTNBCSWealSeviewedtheageandpathologictypeofTNBCandnon—TNBCsResults①Themeanageof

6、1NBCandnonTNBCsWassiganificantlydifferent儼3877，PO05)，andthemeanageofTNBC(51992【3287])WasolderthanthatofER伊R／HEI也(483士89[2668])(尸=0007)②InfiltratingductalcarcinomaWasthemainpathologictypeofallgroups，andbasal—likebreastcan

7、ceraccountedfor477％(83／174)of耶NBCwhileonlylornocaseinnon一11呵BCgroups③TNBCweremorefrequentlyassociatedwithmerelyamass(95／1501633％】)，roundorovalwithindistinctmarginthannonTNBCs∥=81467，PO01)，andthemeandiameterofthemassofTNB

8、C(239341159mm)WaslargerthanthoseofnonTNBCs(辟4619，P=0001)1NBCwerelessfrequentlyassociated、vithmicrocalcifications(9／150【6O％】)thannonⅢBCs∥=31997，POO1)④MammographicdensitywassignificantlydifferentwiththatofER竹，PR／HEI也breast

9、cancer(2／=9381，P=0025)ConclusionThemammographicfeaturesofTNBCthatlesionsshowmerelyamass，roundorovalwithindistinctmargins1agerinsizeandlessassociatedwithmicrocalcificationsmightbeusefulindiagnosingtriplenegativebreastcanc

10、erThemeanageofTNBCis52yearsoldandthemainhistopathologicfindingiSinfiltratingductalcarcinomawithahighproportionofbasallikebreastcancerPostgraduate：CuiChunxiao(Medicalimaging)DirectedbyProfLinQingKeywords=triplenegativebre