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1、 人腦膠質(zhì)細(xì)胞瘤基因啟動(dòng)子超甲基化和組蛋 白修飾的臨床研究人腦膠質(zhì)細(xì)胞瘤基因啟動(dòng)子超甲基化和組蛋 白修飾的臨床研究 劉柏麟 培 養(yǎng) 類 別 全日制 學(xué) 位 類 型 學(xué)術(shù)學(xué)位 一級(jí)學(xué)科(專業(yè)類) 臨床醫(yī)學(xué) 二 級(jí) 學(xué) 科 ( 專 業(yè) ) 外科學(xué)(神外) 研 究 方 向 腦腫瘤的基礎(chǔ)與臨床研究 指 導(dǎo) 教 師 章翔教授(主任醫(yī)師) 培 養(yǎng) 單 位 西京醫(yī)院神經(jīng)外科 二 O 一三年五月 分 類 號(hào) U D C 密 級(jí) 第 四
2、 軍 醫(yī) 大 學(xué)The Fourth Military Medical University博士學(xué)位論文第四軍醫(yī)大學(xué)博士學(xué)位論文 目 錄 縮略語表························
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5、183;··························1 中文摘要·········
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9、·····5 ABSTRACT······························
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12、183;·············10 前 言·····················
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14、#183;····································
15、;···························15 文獻(xiàn)回顧········
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18、3;····································
19、183;···17 正 文·······························
20、83;····································&
21、#183;····································
22、;·················31 第一部分 惡性膠質(zhì)細(xì)胞瘤多基因啟動(dòng)子超甲基化及其預(yù)后意義··············
23、183;············31 1 材料·······················
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25、83;····································&
26、#183;······················32 1.1 膠質(zhì)細(xì)胞瘤組織樣本 ···········
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28、3;····································32
29、 1.2 血清和腦脊液樣本 ··································
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31、·················32 1.3 主要儀器··················
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33、83;····································&
34、#183;············33 1.4 主要試劑······················
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36、3;····································
37、183;········34 2 方法···························
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39、83;····································&
40、#183;··················34 2.1 DNA 提取 ···············
41、83;····································&
42、#183;····································
43、;··············34 2.2 DNA 甲基化免疫共沉淀(MeDIP) ··················
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45、3;·····37 2.3 Real-time PCR····························
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47、3;································40 2.4 統(tǒng)計(jì)學(xué)分析··
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50、3;························43 3 結(jié)果···········&
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53、83;··································43 3.1 膠質(zhì)細(xì)胞瘤腫
54、瘤組織、血清和腦脊液 DNA 中的基因啟動(dòng)子超甲基化 ···43 3.2 基因啟動(dòng)子超甲基化與生存期的關(guān)系·························
55、183;·······························50 4 討論····
56、;····································
57、83;····································&
58、#183;····································
59、;·····58 第二部分 膠質(zhì)細(xì)胞瘤全局性組蛋白修飾及其預(yù)后意義 ···························
60、;···············63 1 材料····················
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