康腦靈膠囊治療非癡呆型血管性認知障礙的臨床和實驗研究.pdf

1、，。i2謄“。汀。?！?。。’。““鼉溉辮y9l_i們7：j灞分類號：密級：單位代碼：10441學號：200301030山孽中匿藹大虧博士學位論文論文題目：康腦靈膠囊治療非癡呆型血管性認知障礙的臨床和實驗研究底研究生姓名王翠蘭入學學科指導學位年月專業(yè)教師類型2003年9月中醫(yī)內(nèi)科學張洪斌醫(yī)學科學學位2006年4月20日ClinicalandExperimentalStudyofTreatingVascularCognitiveImpair

2、mentNoDementiaWithKangNaoLingCapsuleSpecialty：InternalMedicineofTCMAuthor：WangCui—lanTutor：ProfZhangHong—binAbstractobjective：ToobservetheeffectofKangNaoLingcapsuleonthepatientswithvascularcognitiveimpairmentnodementia(V

3、ClND)andexplorethemechanismofitMethods：ComparewithPiracetam，observetheinfluenceofKangNaoLingonthecognitiveabilities，clinicalsymptom，meancerebrovascularbloodflowvetocityhemorheologybloodfat，eventrelatedpotentialP300andvas

4、cularmotorreactivity(VMR)ofpatientssufferedfromVClNDandcheckitssecurityatthesametimeAlsomakeexperimentonratstodeterminetheinfluenceontheabilitytolearnandmemorytheneuronappearanceofthehippocarnpus，expressionofsynaptophysi

5、n(Syn)，rCBFandlong—termpotentiation(LTP)oftheratsmodelwithvascularcognitiveimpairmentby4VOmethodsResults：AfterthetreatmentofKangNaoLingcapsule，thetotalclinicalefficiencyis6140％，neuropsychologicalexaminationssuchasMMSEclo

6、ckdrawingtask(CDT)alettercanceltest(LCT)andcontinuouscalculationtest(CCT)showobviousameliorationofthesufferings’cognitiveabilityThetotalefficiencyofTCMsyndrometherapeuticevaluationis8246％，theclinicalsyndromeamelioratedcl

7、earlyThelatentperiodofevent—relatedpotentialP300decurtatedobviouslyandthewaveamplituderunupclearlyVMRraisedobviouslyTheindexofhemorheology，thecerebrovascularmeanbloodflowvelocityandbloodfatalsohasapparentimprovementcompa

8、redwiththestatesbeforetreatmentThere’SlittleadverseeffectinthetreatmentprogressThesecurityevaluationisgoodInexperimentedstudy，theachievementofthetestees(ratstookKangNaoLingcapsule)aremoregoodthanthecontrasts(ratstookPira

9、cetam)andmodels(ratstooknothing)onplacetestandspatialprobetestTheneuronappearanceofthetestees’hippocampusisregularthere’SnoclearappearanceofischemiaandnecrosisComparewithcontrastsandmodels，there’SmoreexpressionofSynTherC