治療腫瘤的可控陡脈沖裝置及其殺傷腫瘤細胞效果的研究.pdf

1、分類號UDC密級學號彳磨火擎碩士學位論文論文題目：治療腫瘤的可控陡脈沖裝置及其殺傷腫瘤細胞效果的研究論文作者：米彥襲嘉、教7要囂君孫才新教授重慶大學職稱、作單位：孫才瓢教撥重厭大字申請學位級別：碩士專業(yè)名稱：電氣工程論文提交日期：2003年4月10日答辯日期：2003年5月24日學位授予單位：重慶大學授位日期：年月日答辯委員會主席：司馬文霞教授論文評閱人：廖瑞金教授胡麗娜教授2003年5月26日重慶大學碩士論文AbstractCombi

2、mngHighVoltageNewTechnologyandPowerElectronicsTechnologythispaperdevelopedaControllableSteepPulseGenerator(CSPG)thatcancontroltheenergyofoutputpulseaccuratelyAppliedwimthisgeneratoralotofcellexperimentsandanimalexperimen

3、tswerecarriedoutBasedontheseworks，it’SeasiertesearchmechanismofIrreversibleElectricalBreakdown(IREB)ofmalignanttumorcellundersteeppulse，anditmaybehelpfultogeneralizeEnergyControllableSteepPulseTherapy(ECSPnoncancertreatm

4、entAtfirst，producedirectcurrenthighvoltagebySwitchingPowerSupply(sPs)Then，controlthisvoltagetochargeacapacitorthrougharesistorDischargethecapacitortoaloadafterithaschargedfullyenough，andthisproducesallExponentialDecayPul

5、se(EDP)ontheloadAdjustingdigitalpotentiometerincontrollingcircuitsofSPSandcapacitorcharginganddischargingcircuitseparatelywitllIndustryControlComputer(Ice)，thepeakvalueandrepeatfrequencyofoutputpulseCanbeadjustedseparate

6、lyControllingrelaystochoosedifferentcapacitorswitlICCthewidthofoutputpulseCallbeadjustedThen，appliedwithCSPGcellexperimentsonhuman’SovarianadenocarcinomaSKOV3ceilswerecarriedoutTheresultshowsthatsteeppulseCankillandwound

7、malignanttumorcelleffectivelyItCanrestrainDNAsynthesisincellcycle，SOcancercellmultiplicationisrestrainedFinallyappliedwithcsPc‘a(chǎn)nimalexperimentsonBALB／CmiceinoculatedwithcervicalsquamacancerwerecarriedoutTheresultshowsth

8、atsteeppulseCankillandwoundmalignanttBmorcelleffectivelyItCanrestrainthegrowthoftumortissueandprolongsurvivaltimeofthemiceobviouslyThelaboratorydebuggingresultandmedicalexperimentsresultsbothshowthatCSPGhasexcellentperfo

9、rmance，anditsatisfiedtheneedsofmedicalexperimentsfullyandgottheexpectedgoalsuccessfullyThisprovidesthefoundationforapplyingECSPTonclinicalCanCcrtreatmentInaddition，thesemedicalexperimentsresultsalsoshowthatthefutureofECS