西比靈對硝酸甘油致偏頭痛大鼠三叉神經(jīng)核尾部c-fos蛋白表達(dá)的影響.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文西比靈對硝酸甘油致偏頭痛大鼠三叉神經(jīng)核尾部cfos蛋白表達(dá)的影響姓名：郝嘉楠申請學(xué)位級別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：牛爭平20070515山西醫(yī)科大學(xué)硬士學(xué)位論文EffectsofsibeliumoncfosexpressionwithintrigeminalnucleuscaudalisoftheratfollowingglyceryltrinitrateinfusionAbstractObjective：T

2、oobservetheinfluenceofsibeliumOilcfoSexpressionwithintrigeminalnucleuscaudalisoftheratfollowinglomg／kgglyceryltrinitrateinfusionMethods：Theexperimentalmi鏟ameratswererandomlydividedintofourgroups：Shamgroup(GroupI】a6)，Cont

3、rolgroup(GroupII，n=6)，Treatmentgroup(Groupm，n=6)andPreventmentgroup(GroupIVn=6)tomeCkgglyceryltrinitrateinfusiontocopymigraineauimalmodelAccordingtoreference，104ml／kgphysiologicalsalineinfusiontoShamgroup(GroupIn=6)10mg／

4、kgglyceryltrinitrateinfusiontocopymigraineanimalmodelinControlgroup(GroupIIn=6)Treatmentgroup(GrouplHn=6)andPreventmentgroup(GrouplVa=6)In104ml／kgdistilledwaterinfusetostomachcontrolgroupaftercopyingmodel30min104mg／kgsib

5、eliuminfusetostomachconuolgroupaftercopyingmodel15—20min104mg／kgsibeliuminfusetostomachcontrolgroupbeforecopyingmodelaweek4haftercopyingmigraineanimalmodel，1％50mg／kgPentobarbitalt0paralyzeratwhich4mtrigeminalnucleuscauda

6、lis(TNC)removedTheexpressionofcfosimmunoreaetivitywasdetectedwithimmunohistochemicalmethodResults：11：909％ofcopyingmigraineanimalmodelin22ratTheGTNratsappearedreddishtwocars，headshaking，scratchingheadwithforepaws，activity

7、increasingin5—10minpeakedin4060min，kcepedwith13hTheshamratsappearedreddishtwoears，headshaking，scratchingheadwithforepaws，activityincreasingsmallTreatmentgroupandpreventmentgroupdecreasedat60mindisappearedat120min2)：InOLY

8、MPUS，thecellwastastelessinbackground，thepositivecellwasyellowinTNCThepositivecellincontrolgroupwasobviouslyincreasedbetweentreatmentgroupandpreventmentgroup31：Differentgroupsweresignificantdifferenceamongfourgroups(F=203

9、65，Po05)Conclusion：1)：Themodelisagoodonewhich鋤usedforevaluatingdrug’seffectandsmdingpathogenesis2)：Theexperimentalresultsupporttrigeminovasular3)：TheresultsuggestedthatsibeliumcouldchangeCfosexpressionitcouldbeusedtoprev