29886.蔗糖衍生物的制備及其單晶結(jié)構(gòu)和甜味機(jī)理的研究

1、南京理工大學(xué)博士學(xué)位論文蔗糖衍生物的制備及其單晶結(jié)構(gòu)和甜味機(jī)理的研究姓名：溫輝梁申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：生物化工指導(dǎo)教師：方志杰20090828博士論文蔗糖衍生物的制備及其單晶結(jié)構(gòu)、甜味機(jī)理的研究AbstractSucroseisonekindofexcellentnaturalsweetsubstances，butexcesssugarmayresultinanumberofhealthproblemsInrecentyearsfoo

2、dchemistshavebeensearchingforsomesugarsubstituteswithexcellentperformance，especiallymuchattentionhasbeenfocusedonthemodifacationbasedonsucrosetoobtainmoreexcellentsweetnerInthisdissertationthesynthesisoftwokindsoffunctio

3、nalsucrosederivativesraffinoseandhalosucrosewerestudied，andthestructure—activityrelationshipofsucrosederivativesandsweetnessmechanismwerealsostudiedthroughtheanalysistocrystalstructureandmolecularsimulationRaffinoseisafu

4、nctionaloligosaccharide，widelyexistingincottonseed，sugarbeet，andSOon，notonlyhaveavarietyofhealthfunction，butalsoisanimportantstufftosynthsishalosucrosederivativesInthispapercottonseedcakewasusedasrawmaterial，andtheextrac

5、tion，purificationandcrystallizationofraffinosewerefurtherstudied，thedatasshowtheextractionrateofraffinosecouldbeenhancedsignificantlyundercellulaseandpectinaseandthecationexchangeresinhadmoresatisfactoryeffectonthedecolo

6、rthantheanionexchangeresinAbovethis，theantioxygenationofraffinoseonhighunsaturatedsubstancessuchasfishoilandtheeffectofingestingraffinoseontheabsorptionofCaofmousewerealsopreliminarilydiscussedHalosucrosearedeepprocessin

7、gproductofsucrose，ofwhich4，1’，6trichlorosucroseisthemostexcellentsyntheticsweeteneruntilnowandtheywerealwayssynthesizedthroughprotectinganddeprotectingSUGTOSO，followedbyspecializedhalogenation4Dimethylaminopyridine(DMaP)

8、ascatalystwasintroducedtoobtain6，l’，6trichlorotriyl23，4，3’，4’penta—acetylsucrose(TRISPA)；withDMFassolicitationasaferenvironmentfriendlychlorinationagent—solidphosgeneWasusedteplaceSOCl2tosynthesis4，1’，6trichloro一2，3，4，6，

9、4’penta0acetylSUCrOSe(TOSPA)，whichWascharacterizedbysinglexraydiffraction，basedonitTGSWasobtainedfinallyandthereactionconditionswereoptimizedThisthesisreportthesynthesis。of4一chlorosucrose、4，ldichlorosucroseand6ioso4，l’一d

10、ichlorosucrosebasedonTGS，withappreciatedesiccant，alkaiandsolventAlsothereactionconditionshavebeenoptimizedandtheproductswerecharacterizedby‘HNMR、13CNMRandelementanalysisFinkelsteinReactionausefulmethodtosynthesishalosucr