血型與ards ppt課件

1、嚴重創(chuàng)傷及膿毒血癥后ARDS風險或與血型相關(guān),嚴重創(chuàng)傷及膿毒血癥后ARDS風險或與血型相關(guān),ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis.,ABO glycosyltransferases catalyze antigen modifications on

2、 various glycans and glycoproteins and determine the ABO blood types. ABO糖基轉(zhuǎn)移酶能促進各種多聚糖和糖蛋白抗原的改變，并決定人們的ABO血型。,,Blood type A has been associated with increased risk of vascular diseases and differential circulating l

3、evels of proteins related to inflammation and endothelial function. The objective of this study was to determine the association of ABO blood types with ARDS risk in patients with major trauma and severe sepsis已知A型血與血管性

4、疾病風險增加、循環(huán)中炎癥以及內(nèi)皮功能相關(guān)蛋白質(zhì)水平的差異有關(guān)。但其與嚴重創(chuàng)傷和膿毒癥患者的急性呼吸窘迫綜合征（ARDS）之間是否也存在某種關(guān)系目前還不清楚。,We conducted prospective cohort studies in two populations at an urban tertiary referral, level I trauma center. Critically ill patients (n 5

5、 732) presenting after major trauma were followed for 5 days for ARDS development. Additionally, 976 medical patients with severe sepsis were followed for 5 days for ARDS. Multivariable logistic regression was used to ad

6、just for confounders.該項前瞻性隊列研究納入人群包括在一家三級城市的轉(zhuǎn)診中心和Ⅰ級創(chuàng)傷中心內(nèi)就診的2類患者：732例嚴重外傷后的危重患者及976例患有嚴重膿毒癥的內(nèi)科患者。研究人員對這些患者分別進行了為期5天的隨訪，以觀察其ARDS的發(fā)生狀況；并采用多變量logistic回歸分析對相關(guān)混雜因素進行了校正。,ARDS developed in 197 of the 732 trauma patients (27%).

7、 Blood type A was associated with increased ARDS risk among whites (37% vs 24%; adjusted OR, 1.88; 95% CI, 1.14-3.12; P 5 .014), but not blacks (adjusted OR, 0.61; 95% CI, 0.33-1.13; P=.114). ARDS developed in 222 of the

8、 976 patients with severe sepsis (23%). Blood type A was also associated with an increased ARDS risk among whites (31% vs 21%; adjusted OR, 1.67; 95% CI, 1.08-2.59; P=.021) but, again, not among blacks (adjusted OR, 1.17

9、; 95% CI, 0.59-2.33; P=.652).,研究的主要結(jié)果為：在732例外傷患者中，有197例（27%）發(fā)生了ARDS。其中，A型血與白種人ARDS風險增加顯著相關(guān)，調(diào)整后的風險比值比為1.88，但在非裔美國人中則不存在這種相關(guān)性。在976例嚴重膿毒癥患者中，有222例（23%）出現(xiàn)了ARDS。其中，A型血也與白種人ARDS風險的增加相關(guān)，調(diào)整后比值比為1.67；同樣在非裔美國人中也不存在這種相關(guān)性。,Blood ty

10、pe A is associated with an increased risk of ARDS in white patients with major trauma and severe sepsis. These results suggest a role for ABO glycans and glycosyltransferases in ARDS susceptibility.該研究顯示，對于美國白種人而言， A型血與