立克次體屬匯總

1、Rickettsia,徐桂香 王瑩 趙云鵬 張愛娟 張璐嫻 朱玉,Howard Ricketts,立克次體屬 (Rickettsia) 柯克斯體屬 立克次體目 東方體屬 埃立克體屬

2、 巴通體屬,Reckettsiales,Common characters,Obligated intracellular parasites;Related to arthropod vector.;Zoonosis.,Morphology & stains,Arranged irregularly; polymorphismSmall G- bacilli;Giemsa stain:

3、 violet or blue;,Cultural properties,Binary fissionHave both DNA and RNACulture :susceptible animal (guinea pig), yolksac of chick embryo, cell culture.,Resistance,weak, sensitive to antibioticSurvive in low temperatu

4、re and dry conditionSulfanilamide can stimulate reckettsia’s proliferation,Antigenic sturcture,Group specific antigenEndotoxin: similarly to endotoxin of bacteriaSpecy specific antigen membrane protein:Weil-Felix

5、 reaction(外斐反應(yīng)）: Detect anti-rickettsial antibodies in a patients serum by agglutination of the proteus organisms. ( rickettsia posses Ag that cross-react with Ab of the O antigen of certain proteus),Pathogenic me

6、chanism,Pathogenic material,Pathogenicmechanism,Local（ small blood vessels in lymphoid tissue ）,vascular endothelial cells,Fever, headache, rash,(First bacteremia),(Second bacteremia),vessels,,,,Endotoxin 、 Phospholip

7、ase A,Bite or feces of arthropod vector,Pathogenic sites,,,,Pathogenicity,Pathogenic materialsEndotoxin: similarly to endotoxin of bacteria Phospholipase A: lysis the cell membrane and lysosome membrane of the host cel

8、l, causing hemolysisPathogenic mechanism: invade the epithelial cells of small blood vessule,Pathogenic mechanism,Pathogenic material,Pathogenicmechanism,Local（ small blood vessels in lymphoid tissue ）,vascular endot

9、helial cells,Fever, headache, rash,(First bacteremia),(Second bacteremia),vessels,,,,Endotoxin 、 Phospholipase A,Bite or feces of arthropod vector,Pathogenic sites,,,,Infective route,Source:Rickettsiae normally enter the

10、 body (mammalian reservoir) through the bite or feces of an infected arthropod vector.-----arthropod vector: mite, tifck, louse, fleaPathogenic mechanism: invade the epithelial cells of small blood vessule,Pathogenic me

11、chanism,Pathogenic material,Pathogenicmechanism,Local（ small blood vessels in lymphoid tissue ）,vascular endothelial cells,Fever, headache, rash,(First bacteremia),(Second bacteremia),vessels,,,,Endotoxin 、 Phospholip

12、ase A,Bite or feces of arthropod vector,Pathogenic sites,,,,主要病原性立克次體,種類 傳染源 媒介昆蟲 主要臨床表現(xiàn) 免疫力 普氏立克次體 人 人體虱 發(fā)熱、頭痛、皮疹 持久（流行性斑疹傷寒）

13、 神經(jīng)系統(tǒng)、心血管系統(tǒng)損傷斑疹傷寒立克次體 鼠 鼠蚤 發(fā)熱、頭痛、皮疹 持久（地方性斑疹傷寒） 鼠虱 恙蟲病東方體 鼠 恙螨

14、 局部黑色焦痂 持久（恙蟲熱） 發(fā)熱、頭痛、皮疹 內(nèi)臟損害貝納柯克斯體 家畜 蜱

15、發(fā)熱、頭痛 一定程度 （動物間） 心內(nèi)膜炎,,,,Epidemic typhus (R.prowazekii)普氏立克次體,Louse-borne; substandard living condition, poor sanitaion; overwhelming ba

16、cterimia,,,,,Human,Human louse,Human,Human louse,Epidemic typhus (R.prowazekii)普氏立克次體,Fever (temperature rises to 40ºC;Treatment: sanitation, eradication of human lice; vaccine, tetracycline,主要病原性立克次體,

17、種類 傳染源 媒介昆蟲 主要臨床表現(xiàn) 免疫力 普氏立克次體 人 人體虱 發(fā)熱、頭痛、皮疹 持久（流行性斑疹傷寒） 神經(jīng)系統(tǒng)、心血管系統(tǒng)損傷斑疹傷寒立克次體 鼠 鼠蚤

18、 發(fā)熱、頭痛、皮疹 持久（地方性斑疹傷寒） 鼠虱 恙蟲病東方體 鼠 恙螨 局部黑色焦痂 持久（恙蟲熱）

19、 發(fā)熱、頭痛、皮疹 內(nèi)臟損害貝納柯克斯體 家畜 蜱 發(fā)熱、頭痛 一定程度

20、 （動物間） 心內(nèi)膜炎,,,,Endemic typhus (R. mooseri)斑疹傷寒立克次體,Transmitted way:,,,,,,,,,,,,,rat,rat flea,rat louse,rat flea,rat,human louse,human,human,human louse,fever;headack:maculopapular rash,主要病原性立克次體,種

21、類 傳染源 媒介昆蟲 主要臨床表現(xiàn) 免疫力 普氏立克次體 人 人體虱 發(fā)熱、頭痛、皮疹 持久（流行性斑疹傷寒） 神經(jīng)系統(tǒng)、心血管系統(tǒng)損傷斑疹傷寒立克次體 鼠 鼠蚤

22、 發(fā)熱、頭痛、皮疹 持久（地方性斑疹傷寒） 鼠虱 恙蟲病東方體 鼠 恙螨 局部黑色焦痂 持久（恙蟲熱）

23、 發(fā)熱、頭痛、皮疹 內(nèi)臟損害貝納柯克斯體 家畜 蜱 發(fā)熱、頭痛 一定程度

24、 （動物間） 心內(nèi)膜炎,,,,Immunity,Mainly depends on CMIStrong immunity after recovery,Microbiological examination,Specimen : bloodIsolation and culture: guinea pigSerological test: Weil-Felix reaction,Prin

25、ciple of prevention and treatment,Control and eradicate its intermediatehost and reservoir hostSpecificity：Rat lung vaccine（全細胞滅活疫苗）,Treatment,Prevention,Chloramphenicol(氯霉素)Tetracycline(四環(huán)素)Ban-Sulfa drugs(禁用磺胺類藥),T