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1、EDITEDBYSTENRENIUS?LESTERPACKER?ENRIQUECADENASEDITEDBYSTENRENIUS?LESTERPACKER?ENRIQUECADENASMITOCHONDRIALSIGNALINGINHEALTHDISEASEMITOCHONDRIALSIGNALINGINHEALTHDISEASEBIOLOGYISBN:9781439880029978143988002990000K13756Cover
2、image:CourtesyofDr.LucaScrranoUniversityofGeneva.Thepicturerepresentsa3DreconconstructionofthemitochondrialwkinamurineembryonicfibroblastexpressingOPA1aftertransfectionwithmitochondriallytargetedEYFP.Mitochondriahavetrad
3、itionallybeenassociatedwithmetabolicfunctionshoweverrecentresearchhasuncoveredacentralroleftheseganellesincellsignalingcellsurvivalcelldeath.Mitochondrialdysfunctionisafactinmyriadpathophysiologicalconditionsincludingage
4、relatedneurodegenerativedisderscancermetabolicsyndromecardiovulardisease.MitochondrialSignalinginHealthDiseaseexaminesthemesessentialfthemaintenanceofthemitochondrialredox(reductionoxidation)energyaxis.Withcontributionsf
5、romanimpressivecadreofinternationallyrecognizedscientiststhebookdiscussescodinatedmitochondrialfunctionsthatregulatecellfunctionbydiscretesignalingpathways.Topicsdiscussedinclude?Electrontransptenergyproduction?Mitochond
6、rialbiogenesisdynamics?Mitochondrialsignaling?Apoptosisautophagy?Pharmacologysignaling?Epigeicsignaling:mitochondrialmethylationacetylationreactionsAnessentialresourceflifehealthscientistsaswellaspharmaceuticalindustrypr
7、ofessionalsthisvolumehighlightstheimptanceofmitochondrialsignalingitsroleinestablishingharmonizedcommunicationbetweenseveralcellularcompartments.Theinfmationinthisvolumeiscriticaltothosedevelopingmitochondriontargetedthe
8、rapiesaimedatassuagingmitochondrialdysfunctionthespecificfactscontributingtoitsdysfunction.MITOCHONDRIALSIGNALINGINHEALTHDISEASEMITOCHONDRIALSIGNALINGINHEALTHDISEASERENIUSPACKERCADENASRENIUSPACKERCADENASK13756_Cover_mech
9、.indd1511122:24PM1.OxidativeStressinCancerAIDSNeurodegenerativeDiseaseseditedbyLucMontagnierRenOlivierCatherinePasquier2.UnderstingtheProcessofAging:TheRolesofMitochondriaFreeRadicalsAntioxidantseditedbyEnriqueCadenasLes
10、terPacker3.RedoxRegulationofCellSignalingItsClinicalApplicationeditedbyLesterPackerJunjiYodoi4.AntioxidantsinDiabetesManagementeditedbyLesterPackerPeterRsenHansJ.TritschlerGegeL.KingAngeloAzzi5.FreeRadicalsinBrainPathoph
11、ysiologyeditedbyGiuseppePoliEnriqueCadenasLesterPacker6.NutraceuticalsinHealthDiseasePreventioneditedbyKlausKrmerPeterPaulHoppeLesterPacker7.EnvironmentalStresssinHealthDiseaseeditedbyJrgenFuchsLesterPacker8.HbookofAntio
12、xidants:SecondEditionRevisedExpededitedbyEnriqueCadenasLesterPacker9.FlavonoidsinHealthDisease:SecondEditionRevisedExpededitedbyCatherineA.RiceEvansLesterPacker10.Redox–GenomeInteractionsinHealthDiseaseeditedbyJrgenFuchs
13、MaurizioPoddaLesterPacker11.Thiamine:CatalyticMechanismsinNmalDiseaseStateseditedbyFrankJdanMulchS.Patel12.PhytochemicalsinHealthDiseaseeditedbyYongpingBaoRogerFenwick13.CarotenoidsinHealthDiseaseeditedbyNmanI.KrinskySus
14、anT.MayneHelmutSies14.HerbalTraditionalMedicine:MolecularAspectsofHealtheditedbyLesterPackerChoonNamOngBarryHalliwellOXIDATIVESTRESSDISEASESeriesEditsLesterPackerPhDenriquecaDenasMDPhDUniversityofsoUthernCalifniasChoolof
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