不同內(nèi)膜準(zhǔn)備方案對(duì)高齡不孕患者fet的臨床效果比較

1、Ⅰ分類號(hào)：R321 密級(jí)：公開UDC： 610 學(xué)校代碼：11065碩士學(xué)位論文不同內(nèi)膜準(zhǔn)備方案對(duì)高齡不孕患者 不同內(nèi)膜準(zhǔn)備方案對(duì)高齡不孕患者 FET 的臨床效果比較 的臨床效果比較?李華鋒指 導(dǎo) 教 師 吳翠嬌 (教授)學(xué)科專業(yè)名稱 人體解剖與組織胚胎學(xué)論文答辯日期 2017 年 5 月 21 日ⅡAnalysis of different endometrial preparation protocols for the elder

2、infertile patients in the FET cyclesAbstractObjective By comparing the frozen thawed embryo transfer (FET) effects ondifferent infertile elderly women, with the three kind of endometrial preparation schemesretrospectivel

3、y: that is, with the down regulation of combined with estrogen andprogesterone (Down regulation + E-P scheme), hormone replacement cycle (E-P) andnatural cycle for endometrial preparation before FET, to investigate the m

4、oderating effectof gonadotropin releasing hormone agonist(GnRHa) in the regulation of controlledovarian hyperstimulation (COH); to observe its influences to the endometrial receptivity,and the synchronization of the deve

5、lopment of endometrium and ovarian follicle; toexplore the appropriate FET preparation for the treatment of refractory senile infertilewomen.Object and Methods A total of 143 cycles elder women （143 patients） ageing 38~4

6、3years old, who were seeking for frozen-thawed embryo transfer (FET) during March 2014and January 2016 at Reproductive Center in Linyi Women and Children Health CareHospital, Shandong, China, were investigated in this st

7、udy. According to the clinicalsituation and protocols taken for endometrial preparation, 143 patients were classifiedinto three groups: Patients who went through 2 times or more transfer failure and usedGnRHa combined wi

8、th hormone replacement were collected in down-regulated group,Group I (n=50). Those who seek IVF due to the simple tubal factor or the male factor andhave abnormal ovulation, were given hormone replacement, were taken as

9、 the artificialcycle group, Group II (n=45). Those who seek IVF due to the simple tubal factor or theman’s factors and have normal ovulation, were as the natural cycle group, Group III(n=48). Using Transvaginal color Dop

10、pler ultrasonography, the thickness and sonographicappearance of endometrium on the progesterone day for every patient in three groupswere detected, ultrasound monitoring parameters ratings were underwent by relatedindic

11、ators of econometric monitoring, to evaluate the endometrial receptivity. Serum levelof hormones such as estradiol (E2), luteinizing hormone (LH), progesterone (P) andfollicle stimulating hormone (FSH) on the menstrual c

12、ycle second day, the progesteroneday and the transfer day were respectively detected. The differences in endometrialultrasound monitoring parameters ratings, serum level of hormones and clinical outcomeswere analyzed sta

13、tistically and compared among the groups.Results Transvaginal color Doppler ultrasound examination showed that there wasno significant difference with endometrial receptivity index among three groups ofinfertile patients