可溶性聚合物支載的吡唑啉和1，2，4-噁二唑啉類化合物的合成方法學(xué)研究.pdf

1、浙江大學(xué)碩士學(xué)位論文可溶性聚合物支載的吡唑啉和1，2，4噁二唑啉類化合物的合成方法學(xué)研究姓名：張健申請學(xué)位級別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：王彥廣20040101浙江人學(xué)碩上論文ABSTRACTThepolymersupportedsynthesisofsmallheteroeyelicmoleculesiSthesubjectofintenseresearchactivity，sinceitrepresentsoneofthemost

2、promisingwaystogeneratesmallmolecularlibrariesinthefieldofcombinatorialchemistrySubstitutedheterocycliccompoundsofferahighdegreeofstructuraldiversityandhaveproventobebroadlyusefulastherapeuticagentsAsaresultallincreasing

3、rangeandnumberofDharmaceuticallyusefulheterocycliccompoundsrecentlyhavebeenpreparedusingsolid—phaseorliquid—phasemethodologyThisapproachpermitstherapidsynthesisofIargenumbersofindividualcompounds，aswellasmixture—basedcom

4、binatoriallibrariesinashorttimeperiodandfacilitatestheiruseinhigh—throughputscreeningAseriesofpyrazolinesand12，4一oxadiazolineshavebeensynthesizedusingpoly(ethyleneglyc01)(PEG)assupportinthispaperInthefirstchapterofthispa

5、perwereviewedtheoriginationanddevelopmentofsolid—phaseorganicsynthesisandliquid—phaseorganicsynthesis，andintroducedsomeimportantheterocycliccompoundsbythem，InthesecondchapterwefirstdisclosedOurfindingspertainingto1，3dipo

6、larcycloadditionofinsitugeneratednitrileimineandsolublepolymer—supportedpropeneBaseaonepotreactionofPEG—supposedarcylate，aldehyde，hydrazineandCATintoluenewithtrioctylaminegavethecorrespondingPEGsupportedpyrazolinesCleava

7、gefromthesupportundermildconditionsaffordedpyrazolines，Theyieldswereintherangeof7090％andthepuritiesweremorethan89％Inthe“rdchapter，wedescribedtheliquidphasesynthesisofl，24一oxadiazolinesvia1，3dipolarcycloadditionreactionon

8、poly(ethyleneglyc01)support(PEG)1，3dipolarcycloadditionofnitrileoxidegeneratedinsituonsolublepolymer、麗tllavarietyofiminesprovidedcorresponding124一oxadiazolinesingoodyieldsandpurityTheyieldswereintherangeof88—96％andthepur