水作溶劑的不對稱轉(zhuǎn)移氫化及手性環(huán)狀ONNO-型四齒配體的設計合成和應用.pdf

1、廈門大學碩士學位論文水作溶劑的不對稱轉(zhuǎn)移氫化及手性環(huán)狀ONNO型四齒配體的設計合成和應用姓名：邢雁申請學位級別：碩士專業(yè)：工業(yè)催化指導教師：高景星20060701廈門大學工學碩士論文AbsttactAbstract4Il磚thesisISmadeoftwopa豳Thefirstpartdiscribeshighlye伍cientchiralPNNPliwndforasymmetriclrd／isferhydrogenationofaro

2、maticketonesinwaterChiralaromaticalcoholshaveimportantapplicationsonpharmaceuticalindustryAsymmetrictransferhydrogenationofaromaticketc潞isallattractivemethodfortheprepcll嘶onofopticallyactivealcoholsAmonstaparticularlyuse

3、fulmethodisasymmetrictmnsferhydrogenationcatalyzedbymetalcomplexesassociatedwithvariouschira[1igandsandusingPrOHorHCOOH／Et3NashydrogensourceHowevetheseorganicsolventsarehamafifltOtheenvironmentInthecontextofusingattemati

4、vesolventsforgreensynthesiswateriscertainlythemostoutaandingsolventThisdissertationfocusesonthestudiesofasymmetrictransferhydrogenationofaromaticketonecatalzedbychiralPNNPtypeligand／metalcomplexinwaterTheexperimentalresu

5、ltsindicatethatchiralPNNP／[IrHCl2(COD)]2systemisaexcellentcatalyticprecursorforasymmemcWansferhydrogenationofpropiophenoneusingHCOONaashydrogensourceinwaterat60oC，leadingtOthechJlal1phenyl1propanolinupto995％yieldmad877％e

6、eEventhemolecularratioofketonetocatalyst(s／c)isupto8000：188％yieldand845％eearestillobtainedForenantioselectivereductionoftheotheraromaticketoneSwhenPPNClassurfactantwasad6edthecatalyticsystemgiveshighacfifityandenantiosel

7、ectivityinupto99％yieldand98％eerespectivelyThesecondpartofthisthesislousesondesignedsynthesisd越毗甄巾既i蒯onofnewchiralcyclicONNOtypeligandandapplicationinasymmetrichydrogenationChiralligandsdisplayacrucialroleinasymmetriccata

8、lysis“ChiralcyclicligandwillofferseveraladvantagesoverchiralopenchainligandsTheycanpmviedrichcoordinationchemistryandgoodselectivityinca謝ymcreactionThisworkhassynthesizednewchiralcyclic0NN0typeligandbycondensionofsalicyl

9、aldehydeandepicMomhydrintogive13bis(2formylphenoxy)一2propanol，whichlutherreactswithchilddiamineThechirdlcyclicONNOtypeligandshavebeenfullycharacterizedbyIRNMRMSandCDspectraCatalyticstudiesshowedthatchiralcyclic0NN0typeli

10、gands／[IrHCl2(COD)]2systemswereeffectivecatalystsforenantioselectivereductionofvariousaR)maticketOnesforreductionofisobutyrophenone1eadingtothecorrespondingopticalalcoholsinupto944％yieldand915％ee—Keywml畦ChimlPNNP蛄昏nd；Asy