一鍋法合成2-芳基喹唑啉化合物的反應研究.pdf

1、江西師范大學碩士學位論文一鍋法合成2芳基喹唑啉化合物的反應研究姓名：曾玉云申請學位級別：碩士專業(yè)：應用化學指導教師：彭以元20090501AbstractManyquinazolinederivatiyeshavewidespreadapplicationsbecauseoftheirbiologicalactivityQuinazolinederivativesareimportantconstituentsofbiologicall

2、yactivenaturalproductsandprovideabackbonefordesigningpharmacologicallyusefuldrugsandfunctionalorganicmaterialsAlthoughmanymethodsforpreparing2arylquinazolinesareavailable，thereportedprocedureseitherrequiremultistepprepar

3、ationsfromspecialreagents／reactantsorsufferseverelimitationsuchastediousexperimentalprocedureandverypooryieldsThereforeanewalternativerouteforthesynthesisof2arylquinazolinesneedstobeexploredInthiswork，anovel，one—potproce

4、dureforsynthesizingavarietyofquinazolinederivativeshasbeendeveloped2Aryl一1，2，3，4tetrahydroquinazolines，whichwerepreparedbycondensationof2aminobenzylamineandaromaticaldehydes，wereoxidezedwithMn02toformthequinazolinesByscr

5、eeningthereactionconditionssuchassolvents，oxidantsetc，anoptimizedreactionconditionforconstruction2Aryl—quinazolineswasobtainedTheresultsindicatedthatactivitedmanganesedioxideWasaneffeetiveoxidantforthetransformationfrom2

6、Aryl1，2，3，4一tetrahydroquinazolinestothecorresponding2Aryl—quinazolinesGoodyieldwereachievedwhen2aminobenzylaminesreacted、析tharomaticaldehydeswhichcontainelectron—withdraworweakelectrondonatingsubstituentgroupsSincethissy

7、nthesisprocedurehasmanymeritssuchasreadilyavailablereagents，highyields，mildreactionconditions，extremelysimplepurificationprocedures，thismethodshouldprovidequickaccessto2ArylquinazolinesinindustrializationKeywords：2Aryl—q