獨(dú)活抑制阿爾茨海默病Aβ大鼠模型免疫炎性損傷的實(shí)驗(yàn)研究.pdf

1、遼寧中醫(yī)藥大學(xué)博士學(xué)位論文獨(dú)活抑制阿爾茨海默病Aβ大鼠模型免疫炎性損傷的實(shí)驗(yàn)研究姓名：張杰申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：中醫(yī)基礎(chǔ)理論指導(dǎo)教師：李德新20080403美辛可以抑制腦內(nèi)炎性反應(yīng)，但對(duì)抑制凋亡作用不及丹參及獨(dú)活。結(jié)論：l、阿爾茨海默證是以五臟虛損為本，濕痰為標(biāo)，祛風(fēng)勝濕藥獨(dú)活可以通過(guò)干預(yù)阿爾茨海默病的免疫損傷機(jī)制，而發(fā)揮治療作用。2、祛風(fēng)勝濕藥之獨(dú)活可改善郵大鼠的學(xué)習(xí)記憶能力，并通過(guò)抑制A13大鼠腦中IL1、IL一6、TNF—A等細(xì)

2、胞因子的表達(dá)，從而減輕邯大鼠腦中炎性反應(yīng)；對(duì)郵大鼠腦中核轉(zhuǎn)錄因子NF—Kb具有調(diào)節(jié)作用，降低腦中INOS的表達(dá)，進(jìn)而減輕大鼠腦內(nèi)炎性反應(yīng)、細(xì)胞凋亡、氧化應(yīng)激等反應(yīng)，減輕神經(jīng)元細(xì)胞的損害。可通過(guò)抑制p38MAPK信號(hào)通路的轉(zhuǎn)導(dǎo)及調(diào)控凋亡蛋白以減輕腦中的免疫炎性反應(yīng)，從而抑制細(xì)胞凋亡。濕法關(guān)鍵詞：阿爾茨海默病獨(dú)活免疫炎性損傷實(shí)驗(yàn)研究P38MAPK祛風(fēng)勝ABSTRACTProfession：basictheoryofTCMGraduate：Z

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