肝癌衍生生長因子在鼻咽癌中的表達及預(yù)后價值研究.pdf

1、中南大學(xué)碩士學(xué)位論文肝癌衍生生長因子在鼻咽癌中的表達及預(yù)后價值研究姓名：劉華峰申請學(xué)位級別：碩士專業(yè)：內(nèi)科學(xué)腫瘤指導(dǎo)教師：曹培國20080501ABSTRACTobjective：Toevaluatetheexpressionofhepatomaderivedgrowthfactor(HDGF)innasopharyngealcarcinomaanditsrelationshipwithprognosisMethods：Immunohi

2、stochemicaltechniquewasusedtodetectedtheexpressionofHDGFin119nasopharyngealcarcinomatissuesand24normalnasopharyngealepithelialtissuesAtthesametime，theexpressionofvascularendothelialgrowthfactor(VEGF)innasopharyngealcarci

3、nomawasdetectedTheexpressionofHDGF&VEGFandclinicaldatawerecomparedandanalyzedstatisticallyAllpatientswereclassifiedintoHDGFhi曲expressiongroupandHDGFlowexpressiongroupbythemeanofstainingscoreKaplan—MeierandLog—ranktestwer

4、eusedtoanMyzandcomparesurvivalrateofthe2groupsCoxmodelwasusedtostudyprognosticfactorofnasopharyngealcarcinomaResults：TheexpressionofHDGFinnasopharyngealcarcinomatissueswashigherthanthatinnormalnasopharyngealepithelialtis

5、sues(134134032VS4317士1124P=0006)TherewerenorelationshipbetweentheexpressionofHDGFwithage，sexandTstageHoweverthepatientswithhi曲皿GFexpression(芝134)hadahigherlymphnodemetastasisrate(P0001)，distantmetastasisrate(P=O030)andre

6、lapserate(P=O012)ExpressionofHD(珂waspositivlyrelatedtotheexpressionofVEGF(P=O001)Univariateanalysisshowedthatthepatientswimhi曲瑚DGFexpressionhadalower5yearsurvivalratethanthatwith10W皿GFexpression(4833％VS7119％，P=0019)Multi

7、variateanalysisshowedthatHDGFwasanindependentprognosticpredictivefactorfornasopharyngealcarcinoma(RR=1195，P=0026)Conclusions：TheexpressionofHDGFinnasopharyngealcarcinomatissueswashigherthanthatinnormalnasopharyngealepith

8、elialtissuesItwascloselycorrelatedwithlymphnodemetastasis，distantmetastasisandrelapseofnasopharyngealcarcinomaExpressionof曲GFwaspositivlyrelatedtotheexpressionofⅦGFinnasopharyngealcarcinomaHDGFmightbeanindependentprognos