單側(cè)頸內(nèi)動脈重度狹窄-閉塞腦梗死患者的梗死模式及側(cè)支代償研究.pdf

1、單側(cè)頸內(nèi)動脈重度狹窄/閉塞腦梗死患者的梗死模式及側(cè)支代償研究 中文摘要 I 碩士學(xué)位論文 論文題目 單側(cè)頸內(nèi)動脈重度狹窄/閉塞腦梗死患者 的梗死模式及側(cè)支代償研究 研 究 生 姓 名 張 慧 指導(dǎo)教師姓名 趙合慶 專 業(yè) 名 稱 神經(jīng)病學(xué) 研 究 方 向 腦血管病 論文提交日期 2012 年 4 月 單側(cè)頸內(nèi)動脈重度狹窄/閉塞腦梗死患者的梗死模式及側(cè)支代償研究 英文摘要 III Analysis of infarc

2、t patterns and collateral compensation to cerebral infarction patients with the unilateral internal carotid artery severe stenosis or occlusion Abstract Objectives: To analyze the infarct patterns and collateral compensa

3、tion to cerebral infarction patients with the unilateral internal carotid artery（ICA）severe stenosis or occlusion. Methods: Retrospective studying of one hundred and twelve acute ischemic stroke patients. All patients we

4、re divided into ICA disease, middle cerebral artery（MCA）disease,or control group (CG, slightly stenosis group ). According to the infarct lesion were classified as single and multiple, the former was divided into perfora

5、ting artery infarct (PAI), pial infarct(PI) and border-zone infarct(BZ). We studied the infarct patterns according to the DWI performed and analyzed the information about the primary and secondary collateral compensatio

6、n on the basis of DSA. Application of Barthel index and modified Rankin scale, we evaluated the prognosis three months later. Results: Distribution of lesion patterns in three groups might be different(P =0.001). The DWI

7、 multi-infarct pattern was more seen in the two morbid groups; Compared with negative group, pial infarct with perforating artery infarct appeared more often in the ICA lesion group（P =0.005), concomitant perforator with

8、 border-zone infarcts were more seen in the MCA lesion group （P =0.006); The extent of the blood vessel stenosis was connected to the infarct patterns, the more serious of ICA stenosis, concomitant perforator and pial in

9、farcts were more common in patients with ICA disease(P =0.003), and the more heavier of MCA stenosis, concomitant perforator with border-zone infarcts were more often in patients with MCA disease(P =0.043); The incidence

10、 of collateral circulation was 89.66%(52/58), and the incidence of the circle of Willis mixed with the second collateral circulation was 60.34%(35/58), anterior communicating artery, 27.59%(16/58), posterior communicatin