化療與非化療治療軟組織肉瘤療效的系統(tǒng)評價.pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文化療與非化療治療軟組織肉瘤療效的系統(tǒng)評價姓名：馬曉偉申請學(xué)位級別：碩士專業(yè)：外科學(xué)骨科指導(dǎo)教師：白靖平201004新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文—2—AsystematicreviewofchemotherapyversuscontrolintreatingthesofttissuesarcomaPostgraguate:MaXiaoweiSupervis:AssociateprofessBaiJingpingAb

2、stractObjectiv:ToassesseffectivenessofchemotherapyversuscontrolintreatingthesofttissuesarcomaMethods:WesearchedtheMEDLINE（1966～2009.12）、EMBASE（1984～2009.12）、OVIDdatabase（1980～2009.12）、CBMdisc（1980～2009.12）CochraneLibrary

3、ClinicalTrialdatabasehsearchedtheJournalofChineseOncologyJournalofChineseClinicalOncologyTum.Thequalityoftheincludedstudieswasevaluatedbytworeviewersmetaanalysisperfmedftheresultsofthehomogenousstudies.Results:Sixstudies

4、involving836participantsrelatedtoprimaryhighgradenonmetastaticsofttissuesarcomawereincluded.Allincludedstudieswereunclearinreptingromizationblindingallstudiesreptedthenumberthereasonofwithdrawbaselineconditionsofallstudi

5、eswerecompared.Metaanalysisbasedonincludedstudiesshowedthattherewasnoadvantagein5yearOS[RR0.9095%CI(0.761.06)]LocalRecurrence[0.6995%CI(0.361.32)]DistantRecurrence[0.8395%CI(0.621.11)]OverallRecurrence[RR0.9195%CI(0.781.

6、06)]instatisticsignificancebetweenchemotherapygroupcontrolprotocol.But5yaerDFS[RR0.7395%CI(0.630.86)]chemotherapygroupisbetterthancontrolgroup[P=0.0001，RR0.7395%CI(0.630.86)].Conclusions:Thereisnoadvantagefchemotherapygr

7、oupovercontrolgroupin5yearOSLocalRecurrenceDistantRecurrenceOverallRecurrenceDuetoriskofionbiasperfmancebiaspublishedbiastheevidenceisnotstrongenoughtojudgewhetherchemotherapyisbetterthancontrolintreatingsofttissuesarcom