選擇性COX-2抑制劑尼美舒利對(duì)肺癌放射治療增敏作用及其機(jī)制研究.pdf

1、內(nèi)蒙古醫(yī)學(xué)院碩士學(xué)位論文選擇性COX2抑制劑尼美舒利對(duì)肺癌放射治療增敏作用及其機(jī)制研究姓名：劉淑珍申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：內(nèi)科學(xué)指導(dǎo)教師：張卿20100501O內(nèi)蒙古醫(yī)學(xué)院碩士研究生學(xué)位論文(20里Q卑)SelectiveCOX‘——2InhibitorNimesulideontheSensitizingEffectofRadiotherapyofLungCanceranditsMechanismABSTRACTObjectiveToo

2、bservetheselectiveCOX—inhibitorscombinedwithradiotherapy011theA549humanlungadenocarcinomaxenograftsinnudemiceandtofurtherexploretheirapactofthegrowthofitsradiationsensitizingmechanismMethodsFirst，tObuildhumanlungadenocar

3、cinomaA549xenograftsinnudemice，nudemicetransplantedtumortobealong800naftertoamaxhunlof5mmdiameterweredividedintofourgroupsWereaSfol—lows：(1)blankcontrolgroup；(2)，radiotherapyalonegroup；(3)nimesulidegroup；(4)，nimesulideco

4、mbinedwithradiotherapyNimesulidedissolvedin05％CMCmethodusedingavageadministration，thelargesttumordiameter8mmlongtobelocalizedafterasingleKgh—doseradiotherapymGy，observetheexperimentalgroup，tumorgrowthinnudemiceineachgrou

5、p12mmthetimerequiredforrenderingtumorgrowthcurve，growthinhibitionindexandtheinhibitionrateoftumortissuesbyimmunohistochemistrytOdetectPCNA，bex，bcl2expressionintheorganization，theapplicationwasmeasuredbyfloweytometrycellc

6、ycledistribution，apoptosisResultsofthelungcancerbecame奴對(duì)nudetransplanthasadistinctgrowthinhibitiontransplnnt—knobsgrow6mm12mmtheblanksection：(712072)；10cal(834071)；theunitedststeS’group(1129078)；jointgroup(1462148)failur

7、eofthejointgrouphas(471％)thegroup(183％)；localhigherpO05Sjointgroup，thelocal，unitedstates’interestgroupisbelowthepO05andjointgroupoflocalandbelow，theunitedstates’group(pO05)92mofthejointgroup，local，unitedstates’interestgr